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Thbs2 thrombospondin 2 [ Mus musculus (house mouse) ]

Gene ID: 21826, updated on 2-Nov-2024

Summary

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Official Symbol
Thbs2provided by MGI
Official Full Name
thrombospondin 2provided by MGI
Primary source
MGI:MGI:98738
See related
Ensembl:ENSMUSG00000023885 AllianceGenome:MGI:98738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TSP2; Thbs-2
Summary
Predicted to enable calcium ion binding activity and heparin binding activity. Involved in negative regulation of angiogenesis. Located in basement membrane. Is expressed in several structures, including central nervous system; genitourinary system; jaw; mesothelium; and respiratory system. Orthologous to human THBS2 (thrombospondin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 44.4), limb E14.5 (RPKM 28.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Thbs2 in Genome Data Viewer
Location:
17 A2; 17 8.95 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (14885762..14914524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (14665500..14694262, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38551 Neighboring gene VISTA enhancer mm1999 Neighboring gene predicted gene, 34916 Neighboring gene STARR-seq mESC enhancer starr_41894 Neighboring gene predicted gene, 53989 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 23352 Neighboring gene WD repeat domain 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Thrombospondin-2 is an endogenous adipocyte inhibitor. Shitaye HS, et al. Matrix Biol, 2010 Jul. PMID 20561899, Free PMC Article
  2. Low-density lipoprotein receptor-related protein contributes to the antiangiogenic activity of thrombospondin-2 in a murine glioma model. Fears CY, et al. Cancer Res, 2005 Oct 15. PMID 16230396
  3. Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice. Hankenson KD, et al. Matrix Biol, 2005 Aug. PMID 15979292
  4. Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype. Manley E Jr, et al. J Appl Physiol (1985), 2015 Oct 15. PMID 26272319, Free PMC Article
  5. Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice. Agah A, et al. Am J Pathol, 2005 Jul. PMID 15972954, Free PMC Article

See all (133) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.
    Title: Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.
  2. Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice.
    Title: Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice.
  3. Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
    Title: Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
  4. Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
    Title: Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
  5. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
    Title: Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
  6. Thrombospondin-2 spatiotemporal expression in skeletal fractures.
    Title: Thrombospondin-2 spatiotemporal expression in skeletal fractures.
  7. Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis.
    Title: Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis.
  8. TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
    Title: TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
  9. Findings demonstrate a novel link between TSP2, LOX, and miR-29 that is regulated by the presence or absence of TSP2 in the extracellular environment, forming a feedback loop between cells and its extracellular matrix substrate.
    Title: Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.
  10. Though the TSP2-deficient mice developed obesity and hyperglycemia comparable with diabetic control mice, they exhibited significantly improved healing, characterized by accelerated reepithelialization and increased granulation tissue formation, fibroblast migration, and blood vessel maturation.
    Title: Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in platelet alpha granule IEA
Inferred from Electronic Annotation
more info
  
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thrombospondin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011581.3 → NP_035711.2  thrombospondin-2 precursor

    See identical proteins and their annotated locations for NP_035711.2

    Status: VALIDATED

    Source sequence(s)
    AK132508, AK142552, AK165881, CJ049934
    Consensus CDS
    CCDS49958.1
    UniProtKB/Swiss-Prot
    Q03350, Q8CG21
    UniProtKB/TrEMBL
    Q7TMT3
    Related
    ENSMUSP00000128308.2, ENSMUST00000170872.3
    Conserved Domains (10) summary
    smart00209
    Location:497 → 549
    TSP1; Thrombospondin type 1 repeats
    smart00210
    Location:21 → 213
    TSPN; Thrombospondin N-terminal -like domains
    sd00001
    Location:847 → 884
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:789 → 823
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:693 → 728
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam00090
    Location:385 → 430
    TSP_1; Thrombospondin type 1 domain
    pfam00093
    Location:320 → 374
    VWC; von Willebrand factor type C domain
    pfam02412
    Location:848 → 884
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:974 → 1171
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:652 → 691
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    14885762..14914524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03350.2 GenPept UniProtKB/Swiss-Prot:Q03350

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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