Thbs3 thrombospondin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thbs3provided by MGI
Official Full Name: thrombospondin 3provided by MGI
Primary source: MGI:MGI:98739
See related: Ensembl:ENSMUSG00000028047 AllianceGenome:MGI:98739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TSP3; Thbs-3
Summary: Predicted to enable heparin binding activity. Acts upstream of or within bone trabecula formation; growth plate cartilage development; and ossification involved in bone maturation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including brain; lung; musculoskeletal system; sensory organ; and urinary system. Orthologous to human THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 35.8), lung adult (RPKM 25.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.01 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89122470..89134148)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89215180..89226841)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that Thbs3 reduces integrin trafficking to the sarcolemma in the heart, while Thbs4 is cardioprotective by augmenting membrane residence of select integrins and beta-dystroglycan of the glycoprotein attachment complex.
Title: Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within growth plate cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within growth plate cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification involved in bone maturation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thrombospondin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013691.3 → NP_038719.2 thrombospondin-3 precursor

See identical proteins and their annotated locations for NP_038719.2

Status: VALIDATED

Source sequence(s)

AC161600, BC053023, BP754474, CJ064850

Consensus CDS

CCDS17495.1

UniProtKB/Swiss-Prot

Q05895, Q6LCE0, Q7TN15

UniProtKB/TrEMBL

E9PWF0

Related

ENSMUSP00000029682.5, ENSMUST00000029682.11

Conserved Domains (9) summary

cd00054
Location:316 → 352

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00001
Location:528 → 550

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:551 → 586

TSP3; TSP3 repeat_long [structural motif]

sd00003
Location:457 → 491

TSP3_1C; TSP3 repeat_1C [structural motif]

pfam02412
Location:552 → 586

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:741 → 938

TSP_C; Thrombospondin C-terminal region

pfam12947
Location:378 → 407

EGF_3; EGF domain

cd16079
Location:227 → 269

TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)

cl22861
Location:21 → 193

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RNA

NR_149740.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC132327, AC161600, BP754474

Related

ENSMUST00000126315.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

89122470..89134148

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501295.3 → XP_006501358.1 thrombospondin-3 isoform X1

Conserved Domains (8) summary

cd00054
Location:111 → 147

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00001
Location:323 → 345

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:346 → 381

TSP3; TSP3 repeat_long [structural motif]

sd00003
Location:252 → 286

TSP3_1C; TSP3 repeat_1C [structural motif]

pfam02412
Location:346 → 381

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:536 → 733

TSP_C; Thrombospondin C-terminal region

pfam12947
Location:173 → 202

EGF_3; EGF domain

NF000535
Location:257 → 447

MSCRAMM_SdrC; MSCRAMM family adhesin SdrC