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Cdc14b CDC14 cell division cycle 14B [ Mus musculus (house mouse) ]

Gene ID: 218294, updated on 14-Nov-2024

Summary

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Official Symbol
Cdc14bprovided by MGI
Official Full Name
CDC14 cell division cycle 14Bprovided by MGI
Primary source
MGI:MGI:2441808
See related
Ensembl:ENSMUSG00000033102 AllianceGenome:MGI:2441808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDC14B3; Cdc14B1; 2810432N10Rik; A530086E13Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including positive regulation of ubiquitin protein ligase activity; protein dephosphorylation; and regulation of cell cycle process. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; nucleolus; and spindle. Is expressed in embryo. Orthologous to several human genes including CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 6.1), placenta adult (RPKM 2.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc14b in Genome Data Viewer
Location:
13 B3; 13 33.26 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64337085..64423670, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64192545..64274988, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34820 Neighboring gene zinc finger protein 367 Neighboring gene STARR-positive B cell enhancer ABC_E5404 Neighboring gene STARR-positive B cell enhancer ABC_E928 Neighboring gene STARR-positive B cell enhancer ABC_E7250 Neighboring gene hyaluronic acid binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_34826 Neighboring gene predicted gene, 46424 Neighboring gene RIKEN cDNA 1810034E14 gene Neighboring gene peroxiredoxin like 2C Neighboring gene STARR-seq mESC enhancer starr_34827 Neighboring gene STARR-positive B cell enhancer ABC_E8894 Neighboring gene STARR-positive B cell enhancer ABC_E1879 Neighboring gene predicted gene, 31128

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos. Buffone MG, et al. Cell Cycle, 2009 Dec. PMID 19923902, Free PMC Article
  2. The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Chiesa M, et al. Cell Cycle, 2011 May 15. PMID 21502810
  3. CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes. Schindler K, et al. Biol Reprod, 2009 Apr. PMID 19129509, Free PMC Article
  4. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Lin H, et al. Mol Cell Biol, 2015 Nov. PMID 26283732, Free PMC Article
  5. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Guillamot M, et al. Sci Rep, 2011. PMID 22355704, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
    Title: Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
  2. Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
    Title: Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
  3. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
    Title: Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.
  4. Cdc14B has oncogenic activity in mammals and point to the Ras-MAP kinase pathway as a major effector pathway during oncogenic transformation.
    Title: The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.
  5. Cdc14b is required for efficient DNA damage repair.
    Title: Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.
  6. CDC14B is a negative regulator of the 1-to-2-cell transition and of zygotic genome activation in mouse embryogenesis.
    Title: Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.
  7. CDC14B is a negative regulator of meiotic resumption and may regulate meiosis I in mouse oocytes.
    Title: CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase CDC14B
Names
CDC14 cell division cycle 14 homolog B
NP_001116461.1
NP_766175.3
XP_006517282.1
XP_006517290.1
XP_006517292.1
XP_011242817.1
XP_036013890.1
XP_036013891.1
XP_036013892.1
XP_036013893.1
XP_036013894.1
XP_036013895.1
XP_036013896.1
XP_036013897.1
XP_036013898.1
XP_036013899.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122989.1 → NP_001116461.1  dual specificity protein phosphatase CDC14B isoform 2

    See identical proteins and their annotated locations for NP_001116461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in the use of a novel start codon and a protein (isoform 2) with a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036045, AK041155, BY199064
    Consensus CDS
    CCDS49292.1
    UniProtKB/Swiss-Prot
    Q6PFY9
    Related
    ENSMUSP00000105391.3, ENSMUST00000109769.10
    Conserved Domains (2) summary
    pfam14671
    Location:17 → 151
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:209 → 323
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_172587.3 → NP_766175.3  dual specificity protein phosphatase CDC14B isoform 1

    See identical proteins and their annotated locations for NP_766175.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK036045, AK041155, AK044332, CN720173
    Consensus CDS
    CCDS26598.1
    UniProtKB/Swiss-Prot
    Q6PFY9, Q80WC4, Q8BLV5
    Related
    ENSMUSP00000046003.9, ENSMUST00000039318.16
    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64337085..64423670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158005.1 → XP_036013898.1  dual specificity protein phosphatase CDC14B isoform X11

    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  2. XM_036157997.1 → XP_036013890.1  dual specificity protein phosphatase CDC14B isoform X1

    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  3. XM_036158001.1 → XP_036013894.1  dual specificity protein phosphatase CDC14B isoform X6

    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  4. XM_036158000.1 → XP_036013893.1  dual specificity protein phosphatase CDC14B isoform X5

    UniProtKB/TrEMBL
    A0A1Y7VJB9
    Related
    ENSMUSP00000152388.2, ENSMUST00000221634.2
    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  5. XM_036157998.1 → XP_036013891.1  dual specificity protein phosphatase CDC14B isoform X3

    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  6. XM_006517227.4 → XP_006517290.1  dual specificity protein phosphatase CDC14B isoform X10

    Conserved Domains (2) summary
    cd14499
    Location:162 → 335
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    pfam14671
    Location:13 → 151
    DSPn; Dual specificity protein phosphatase, N-terminal half

  7. XM_036157999.1 → XP_036013892.1  dual specificity protein phosphatase CDC14B isoform X4

    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  8. XM_036158006.1 → XP_036013899.1  dual specificity protein phosphatase CDC14B isoform X13

    Conserved Domains (1) summary
    cd14499
    Location:10 → 183
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

  9. XM_006517229.3 → XP_006517292.1  dual specificity protein phosphatase CDC14B isoform X12

    Conserved Domains (1) summary
    cd14499
    Location:10 → 183
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

  10. XM_006517219.1 → XP_006517282.1  dual specificity protein phosphatase CDC14B isoform X2

    Conserved Domains (2) summary
    cd14499
    Location:162 → 335
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    pfam14671
    Location:13 → 151
    DSPn; Dual specificity protein phosphatase, N-terminal half

  11. XM_011244515.4 → XP_011242817.1  dual specificity protein phosphatase CDC14B isoform X9

    Conserved Domains (2) summary
    cd14499
    Location:104 → 277
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    pfam14671
    Location:1 → 93
    DSPn; Dual specificity protein phosphatase, N-terminal half

  12. XM_036158003.1 → XP_036013896.1  dual specificity protein phosphatase CDC14B isoform X7

    UniProtKB/Swiss-Prot
    Q6PFY9, Q80WC4, Q8BLV5
    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  13. XM_036158004.1 → XP_036013897.1  dual specificity protein phosphatase CDC14B isoform X8

    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  14. XM_036158002.1 → XP_036013895.1  dual specificity protein phosphatase CDC14B isoform X7

    UniProtKB/Swiss-Prot
    Q6PFY9, Q80WC4, Q8BLV5
    Conserved Domains (2) summary
    cd14499
    Location:199 → 372
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:52 → 190
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RNA

  1. XR_004938019.1 RNA Sequence

  2. XR_004938022.1 RNA Sequence

  3. XR_004938021.1 RNA Sequence

  4. XR_873438.3 RNA Sequence

  5. XR_004938020.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFY9.1 GenPept UniProtKB/Swiss-Prot:Q6PFY9

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