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Zfp595 zinc finger protein 595 [ Mus musculus (house mouse) ]

Gene ID: 218314, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp595provided by MGI
Official Full Name
zinc finger protein 595provided by MGI
Primary source
MGI:MGI:3040707
See related
Ensembl:ENSMUSG00000057842 AllianceGenome:MGI:3040707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rslcan23; A230042K10Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in testis and thyroid gland. Orthologous to several human genes including ZNF493 (zinc finger protein 493); ZNF595 (zinc finger protein 595); and ZNF681 (zinc finger protein 681). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 1.3), limb E14.5 (RPKM 0.8) and 24 other tissues See more
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Genomic context

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See Zfp595 in Genome Data Viewer
Location:
13 B3; 13 34.54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67461049..67491018, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67312985..67342954, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F630042J09 gene Neighboring gene STARR-seq mESC enhancer starr_34898 Neighboring gene zinc finger protein 457 Neighboring gene STARR-positive B cell enhancer ABC_E3086 Neighboring gene zinc finger protein 953 Neighboring gene STARR-positive B cell enhancer ABC_E9880 Neighboring gene predicted gene 17039 Neighboring gene zinc finger protein 456 Neighboring gene STARR-positive B cell enhancer ABC_E4075 Neighboring gene zinc finger protein 429

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zin finger protein 595
Names
KRAB zinc finger protein
regulator of sex-limitation candidate 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374733.1 → NP_001361662.1  zin finger protein 595 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154510, AC164116
    Consensus CDS
    CCDS88476.1
    UniProtKB/TrEMBL
    B9EIT6
    Related
    ENSMUSP00000127010.2, ENSMUST00000171466.2
    Conserved Domains (4) summary
    smart00349
    Location:2 → 60
    KRAB; krueppel associated box
    COG5048
    Location:107 → 490
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:493 → 563
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:248 → 268
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_177622.3 → NP_808290.1  zin finger protein 595 isoform 1

    See identical proteins and their annotated locations for NP_808290.1

    Status: VALIDATED

    Source sequence(s)
    AK136304, BB632383, BK001632
    Consensus CDS
    CCDS36712.1
    UniProtKB/TrEMBL
    Q8BIN6
    Related
    ENSMUSP00000105357.3, ENSMUST00000109735.9
    Conserved Domains (4) summary
    smart00349
    Location:5 → 63
    KRAB; krueppel associated box
    COG5048
    Location:110 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:496 → 566
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:251 → 271
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67461049..67491018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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