Wdr41 WD repeat domain 41 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr41provided by MGI
Official Full Name: WD repeat domain 41provided by MGI
Primary source: MGI:MGI:2445123
See related: Ensembl:ENSMUSG00000042015 AllianceGenome:MGI:2445123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MSTP048; B830029I03Rik
Summary: This gene encodes a protein of unknown function, but which contains a WD40 domain consisting of six WD40 repeats. The WD40 domain is one of the most abundant protein domains in eukaryotes, and is found in proteins with widely varying cellular functions. However, proteins with this domain often provide a rigid scaffold for protein-protein interactions. [provided by RefSeq, Aug 2012]
Expression: Ubiquitous expression in CNS E18 (RPKM 6.7), cerebellum adult (RPKM 6.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3- D1; 13 49.22 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (95112226..95161800)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (94976329..95023316)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	ISO Inferred from Sequence Orthology more info
part_of Atg1/ULK1 kinase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
part_of guanyl-nucleotide exchange factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WD repeat-containing protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172590.4 → NP_766178.2 WD repeat-containing protein 41

See identical proteins and their annotated locations for NP_766178.2

Status: VALIDATED

Source sequence(s)

AK046853, AK082348, AK149993, BM943554, BQ043504

Consensus CDS

CCDS56896.2

UniProtKB/Swiss-Prot

Q3UDP0, Q8C4F1, Q8C8K5

Related

ENSMUSP00000124033.2, ENSMUST00000160801.8

Conserved Domains (2) summary

sd00039
Location:87 → 133

7WD40; WD40 repeat [structural motif]

cl29593
Location:38 → 350

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

95112226..95161800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158015.1 → XP_036013908.1 WD repeat-containing protein 41 isoform X1

UniProtKB/Swiss-Prot

Q3UDP0, Q8C4F1, Q8C8K5

Conserved Domains (2) summary

sd00039
Location:87 → 133

7WD40; WD40 repeat [structural motif]

cl29593
Location:38 → 350

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006517584.4 → XP_006517647.1 WD repeat-containing protein 41 isoform X2

Conserved Domains (2) summary

sd00039
Location:98 → 154

7WD40; WD40 repeat [structural motif]

cl29593
Location:87 → 304

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...