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Depdc1b DEP domain containing 1B [ Mus musculus (house mouse) ]

Gene ID: 218581, updated on 2-Nov-2024

Summary

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Official Symbol
Depdc1bprovided by MGI
Official Full Name
DEP domain containing 1Bprovided by MGI
Primary source
MGI:MGI:2145425
See related
Ensembl:ENSMUSG00000021697 AllianceGenome:MGI:2145425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XTP1; 9830132O03
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in cell migration and positive regulation of Wnt signaling pathway. Is expressed in genital tubercle; limb; and limb mesenchyme. Orthologous to human DEPDC1B (DEP domain containing 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14 (RPKM 4.2), liver E14.5 (RPKM 3.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Depdc1b in Genome Data Viewer
Location:
13 D2.1; 13 59.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (108452592..108526100)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (108316014..108389566)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 7 Neighboring gene predicted gene, 30747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:109087570-109087807 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:109087883-109088036 Neighboring gene STARR-positive B cell enhancer mm9_chr13:109106315-109106616 Neighboring gene neuroepithelial cell transforming gene 1 pseudogene Neighboring gene predicted gene, 41056 Neighboring gene predicted gene, 32450

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DEPDC1B is a key regulator of myoblast proliferation in mouse and man. Figeac N, et al. Cell Prolif, 2020 Jan. PMID 31825138, Free PMC Article
  2. Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis. Li W, et al. Biochem Genet, 2023 Oct. PMID 36913076
  3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DEP domain-containing protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418947.1 → NP_001405876.1  DEP domain-containing protein 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161252, CT030256

  2. NM_001418948.1 → NP_001405877.1  DEP domain-containing protein 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161252, CT030256

  3. NM_178683.5 → NP_848798.1  DEP domain-containing protein 1B isoform 1

    See identical proteins and their annotated locations for NP_848798.1

    Status: VALIDATED

    Source sequence(s)
    AC161252, CT030256
    Consensus CDS
    CCDS26762.1
    UniProtKB/Swiss-Prot
    Q810T1, Q8BH88, Q8BZ67
    UniProtKB/TrEMBL
    A7MCV2
    Related
    ENSMUSP00000059291.6, ENSMUST00000051594.12
    Conserved Domains (2) summary
    cd04405
    Location:177 → 400
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cl02442
    Location:15 → 106
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    108452592..108526100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517614.5 → XP_006517677.1  DEP domain-containing protein 1B isoform X3

    Conserved Domains (1) summary
    cd04405
    Location:28 → 251
    RhoGAP_BRCC3-like; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH88.1 GenPept UniProtKB/Swiss-Prot:Q8BH88

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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