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Paip1 polyadenylate binding protein-interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 218693, updated on 2-Nov-2024

Summary

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Official Symbol
Paip1provided by MGI
Official Full Name
polyadenylate binding protein-interacting protein 1provided by MGI
Primary source
MGI:MGI:2384993
See related
Ensembl:ENSMUSG00000025451 AllianceGenome:MGI:2384993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAIP-1
Summary
Predicted to enable translation activator activity. Predicted to be involved in positive regulation by host of viral process and post-transcriptional regulation of gene expression. Predicted to act upstream of with a positive effect on viral translation. Predicted to be located in cytosol. Predicted to be part of mCRD-mediated mRNA stability complex. Predicted to be active in cytoplasm. Is expressed in medial ganglionic eminence. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.1), adrenal adult (RPKM 8.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Paip1 in Genome Data Viewer
Location:
13 D2.3; 13 67.22 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (119564960..119596858)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (119428331..119460323)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35797 Neighboring gene STARR-seq mESC enhancer starr_35799 Neighboring gene STARR-seq mESC enhancer starr_35800 Neighboring gene STARR-seq mESC enhancer starr_35802 Neighboring gene STARR-seq mESC enhancer starr_35803 Neighboring gene STARR-seq mESC enhancer starr_35804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:120196902-120197103 Neighboring gene RIKEN cDNA 4833420G17 gene Neighboring gene STARR-positive B cell enhancer ABC_E7292 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene RIKEN cDNA 3110070M22 gene Neighboring gene STARR-seq mESC enhancer starr_35805 Neighboring gene predicted gene 9752 Neighboring gene transmembrane protein 267

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma. Xie H, et al. Head Neck, 2020 Dec. PMID 32827170
  2. Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†. He Y, et al. Biol Reprod, 2019 Feb 1. PMID 30295753
  3. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1. Yin G, et al. Arch Biochem Biophys, 2024 Apr. PMID 38341068
  4. Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Martineau Y, et al. Mol Cell Biol, 2014 Mar. PMID 24396066, Free PMC Article
  5. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Yu J, et al. Genome Biol, 2003. PMID 14519200, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
    Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
  2. Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma.
    Title: Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma.
  3. PAIP1 regulates the translation of YBX2-masked mRNAs during spermiogenesis.
    Title: Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_positive_effect viral translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of mCRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyadenylate-binding protein-interacting protein 1
Names
PABP-interacting protein 1
poly(A)-binding protein-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079849.3 → NP_001073318.1  polyadenylate-binding protein-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001073318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC163689
    Consensus CDS
    CCDS36791.1
    UniProtKB/TrEMBL
    D3Z3J6
    Related
    ENSMUSP00000104826.3, ENSMUST00000109203.9
    Conserved Domains (1) summary
    pfam02854
    Location:48 → 264
    MIF4G; MIF4G domain

  2. NM_145457.5 → NP_663432.1  polyadenylate-binding protein-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_663432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163689
    Consensus CDS
    CCDS26796.1
    UniProtKB/Swiss-Prot
    Q8VE62, Q9WUC9
    UniProtKB/TrEMBL
    F6Y616
    Related
    ENSMUSP00000026520.8, ENSMUST00000026520.14
    Conserved Domains (1) summary
    pfam02854
    Location:81 → 297
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    119564960..119596858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE62.1 GenPept UniProtKB/Swiss-Prot:Q8VE62

Gene LinkOut

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