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Tlr1 toll-like receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 21897, updated on 2-Nov-2024

Summary

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Official Symbol
Tlr1provided by MGI
Official Full Name
toll-like receptor 1provided by MGI
Primary source
MGI:MGI:1341295
See related
Ensembl:ENSMUSG00000044827 AllianceGenome:MGI:1341295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including Toll-like receptor 2 binding activity; identical protein binding activity; and lipopeptide binding activity. Involved in positive regulation of interleukin-6 production and positive regulation of tumor necrosis factor production. Acts upstream of or within defense response. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Predicted to be active in plasma membrane. Is expressed in brain; cerebral cortex; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 12.1), colon adult (RPKM 6.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Tlr1 in Genome Data Viewer
Location:
5 C3.1; 5 33.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65082023..65090945, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (64924680..64933600, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8057 Neighboring gene STARR-positive B cell enhancer ABC_E8058 Neighboring gene predicted gene, 31889 Neighboring gene STARR-seq mESC enhancer starr_13250 Neighboring gene toll-like receptor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1051 Neighboring gene STARR-positive B cell enhancer ABC_E2745 Neighboring gene STARR-positive B cell enhancer ABC_E2158 Neighboring gene toll-like receptor 6 Neighboring gene family with sequence similarity 114, member A1 Neighboring gene microRNA 574 Neighboring gene STARR-seq mESC enhancer starr_13253 Neighboring gene STARR-seq mESC enhancer starr_13254 Neighboring gene predicted gene, 32374 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:65397377-65397486

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. Sugiura Y, et al. Mucosal Immunol, 2013 Nov. PMID 23443468, Free PMC Article
  2. House Dust Mite Increases pro-Th2 Cytokines IL-25 and IL-33 via the Activation of TLR1/6 Signaling. Jang YH, et al. J Invest Dermatol, 2017 Nov. PMID 28684329
  3. γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages. Ryu YK, et al. J Leukoc Biol, 2015 Apr. PMID 25632046
  4. Regulation of toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia. Stridh L, et al. J Neuroinflammation, 2011 May 10. PMID 21569241, Free PMC Article
  5. Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6. Rubino I, et al. J Infect Dis, 2012 Mar 15. PMID 22315281

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206[+] macrophages[IL-10] activation.
    Title: Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206(+) macrophages(IL-10) activation.
  2. The findings demonstrate that sensing of the microbiota by TLR1 may provide key signals that regulate the colonic epithelium, thereby limiting inflammation through the prevention of bacterial attachment to the mucosa and exposure to the underlying immune system.
    Title: Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation.
  3. These studies reveal that the costimulatory effects of TLR1-TLR2 signaling in CD8(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response.
    Title: Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects.
  4. Activation of MyD88-dependent TLR1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders.
    Title: Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.
  5. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination, modulated by BCR and CD40 in mounting of T-cell independent antibody responses.
    Title: B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses.
  6. TLR9 modulates TLR1 expression in Leishmania major-infected macrophages.
    Title: TLR9-deficiency reduces TLR1, TLR2 and TLR3 expressions in Leishmania major-infected macrophages.
  7. Postradiotherapeutic NO production was dependent on TLR1 gene expression. Although iNOS activity was reduced by inhibiting TLR1 expression with TLR1-siRNA, it was enhanced by TLR1 overexpression.
    Title: γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages.
  8. lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface.
    Title: Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.
  9. We found that CEP specifically synergizes with low-dose TLR2-agonists (but not agonists for other TLRs) to induce production of inflammatory cytokines. Moreover, CEP selectively augments TLR2/TLR1-signaling instead of TLR2/TLR6-signaling
    Title: The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages.
  10. IkappaB-zeta regulates TLR-mediated CSR by inducing AID
    Title: Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables Toll-like receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Toll-like receptor 2 binding IEA
Inferred from Electronic Annotation
more info
  
enables Toll-like receptor 2 binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipopeptide binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables triacyl lipopeptide binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cellular response to triacyl bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to triacyl bacterial lipopeptide ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within detection of triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of triacyl bacterial lipopeptide NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-8 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to bacterial lipoprotein ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in phagocytic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
toll-like receptor 1
Names
TIL
toll/interleukin-1 receptor-like protein
NP_001263374.1
NP_109607.1
XP_006503914.1
XP_006503916.1
XP_006503917.1
XP_006503919.1
XP_011239022.1
XP_030110223.1
XP_036020886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276445.1 → NP_001263374.1  toll-like receptor 1 precursor

    See identical proteins and their annotated locations for NP_001263374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC161757
    Consensus CDS
    CCDS19302.1
    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Related
    ENSMUSP00000142500.2, ENSMUST00000197315.5
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_030682.2 → NP_109607.1  toll-like receptor 1 precursor

    See identical proteins and their annotated locations for NP_109607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC161757, AY009154
    Consensus CDS
    CCDS19302.1
    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Related
    ENSMUSP00000060793.5, ENSMUST00000059349.6
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65082023..65090945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503854.2 → XP_006503917.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503917.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_006503853.3 → XP_006503916.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503916.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

  3. XM_030254363.2 → XP_030110223.1  toll-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_006503856.3 → XP_006503919.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503919.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

  5. XM_036164993.1 → XP_036020886.1  toll-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

  6. XM_006503851.4 → XP_006503914.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006503914.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]

  7. XM_011240720.4 → XP_011239022.1  toll-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011239022.1

    UniProtKB/Swiss-Prot
    Q9EPQ1, Q9EPW5
    UniProtKB/TrEMBL
    B9EJ46, Q6A0E8
    Conserved Domains (6) summary
    PRK15370
    Location:377 → 487
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:48 → 317
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPQ1.1 GenPept UniProtKB/Swiss-Prot:Q9EPQ1

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