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Ttc5 tetratricopeptide repeat domain 5 [ Mus musculus (house mouse) ]

Gene ID: 219022, updated on 28-Oct-2024

Summary

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Official Symbol
Ttc5provided by MGI
Official Full Name
tetratricopeptide repeat domain 5provided by MGI
Primary source
MGI:MGI:2683584
See related
Ensembl:ENSMUSG00000006288 AllianceGenome:MGI:2683584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA binding activity and chromatin binding activity. Involved in DNA damage response and cellular response to starvation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in several cellular components, including cytoplasmic vesicle; cytosol; and mitochondrion. Orthologous to human TTC5 (tetratricopeptide repeat domain 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.7), CNS E11.5 (RPKM 17.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ttc5 in Genome Data Viewer
Location:
14 C1; 14 26.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51002866..51022977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50765409..50785520, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24316 Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene cyclin B1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E753 Neighboring gene ribonuclease P RNA component H1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury. Pressly JD, et al. Sci Rep, 2017 Mar 3. PMID 28256593, Free PMC Article
  2. A new effector pathway links ATM kinase with the DNA damage response. Demonacos C, et al. Nat Cell Biol, 2004 Oct. PMID 15448695
  3. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. Maniam S, et al. Cell Death Differ, 2015 Jan. PMID 25168243, Free PMC Article
  4. A transcription cofactor required for the heat-shock response. Xu D, et al. EMBO Rep, 2008 Jul. PMID 18451878, Free PMC Article
  5. LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. Hu X, et al. J Cell Biol, 2019 Jan 7. PMID 30420355, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38092, 5930437N14

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetratricopeptide repeat protein 5
Names
TPR repeat protein 5
protein Strap
stress-responsive activator of p300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080949.2 → NP_001074418.1  tetratricopeptide repeat protein 5 isoform a

    See identical proteins and their annotated locations for NP_001074418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC027184, AC140280, AK044781, AK133953, AK161279, BY278375
    Consensus CDS
    CCDS36905.1
    UniProtKB/Swiss-Prot
    Q3TTN5, Q3TZL6, Q99LG4
    UniProtKB/TrEMBL
    Q8C8M9
    Related
    ENSMUSP00000006451.7, ENSMUST00000006451.8
    Conserved Domains (3) summary
    sd00006
    Location:68 → 97
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:67 → 130
    TPR_11; TPR repeat
    pfam16669
    Location:318 → 430
    TTC5_OB; Tetratricopeptide repeat protein 5 OB fold domain

  2. NM_001360545.1 → NP_001347474.1  tetratricopeptide repeat protein 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC027184, AK044781, AK133953, AK161279, BY278375

  3. NM_177625.4 → NP_808293.1  tetratricopeptide repeat protein 5 isoform b

    See identical proteins and their annotated locations for NP_808293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027184, AK081214, AW046075, BY278375
    Consensus CDS
    CCDS88650.1
    UniProtKB/TrEMBL
    A0A2I3BRU0, Q8BNN3
    Related
    ENSMUSP00000154412.2, ENSMUST00000226768.2
    Conserved Domains (2) summary
    sd00006
    Location:68 → 97
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:67 → 130
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51002866..51022977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LG4.2 GenPept UniProtKB/Swiss-Prot:Q99LG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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