U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 219024, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Pip4p1provided by MGI
Official Full Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1provided by MGI
Primary source
MGI:MGI:2448501
See related
Ensembl:ENSMUSG00000035953 AllianceGenome:MGI:2448501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem55b
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Involved in positive regulation of TORC1 signaling and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle and plasma membrane. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 44.4), mammary gland adult (RPKM 32.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pip4p1 in Genome Data Viewer
Location:
14 C1; 14 26.3 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51164672..51168306, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50927215..50931010, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene Apex1 promoter region Neighboring gene apurinic/apyrimidinic endonuclease 1 Neighboring gene STARR-seq mESC enhancer starr_36659 Neighboring gene STARR-positive B cell enhancer ABC_E7308 Neighboring gene predicted gene, 52117 Neighboring gene purine-nucleoside phosphorylase Neighboring gene predicted gene, 38316 Neighboring gene purine-nucleoside phosphorylase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease. Odfalk KF, et al. Hippocampus, 2024 Jan. PMID 37961834,
  2. Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. Takemasu S, et al. J Biochem, 2019 Aug 1. PMID 31329883
  3. Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation. Qin Y, et al. Arterioscler Thromb Vasc Biol, 2020 May. PMID 32188273, Free PMC Article
  4. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. Morioka S, et al. J Cell Sci, 2018 Mar 6. PMID 29378918
  5. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Ungewickell A, et al. Proc Natl Acad Sci U S A, 2005 Dec 27. PMID 16365287, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC118137

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in proton-transporting V-type ATPase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to sterol depletion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to sterol depletion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in phagocytic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
PtdIns-4,5-P(2) 4-phosphatase type I
ptdIns-4,5-P2 4-Ptase I
transmembrane protein 55b
type 1 PtdIns-4,5-P2 4-Ptase
type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase
NP_001028443.1
NP_001297434.1
NP_001297435.1
NP_001297436.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033271.5 → NP_001028443.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1

    See identical proteins and their annotated locations for NP_001028443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK144251, BE943635
    Consensus CDS
    CCDS27028.1
    UniProtKB/Swiss-Prot
    Q3TWL2
    Related
    ENSMUSP00000124782.2, ENSMUST00000160835.9
    Conserved Domains (1) summary
    pfam09788
    Location:4 → 277
    Tmemb_55A; Transmembrane protein 55A

  2. NM_001310505.1 → NP_001297434.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK144251, BE943635, BY071053
    Consensus CDS
    CCDS79324.1
    UniProtKB/TrEMBL
    F8WHW3
    Related
    ENSMUSP00000038276.8, ENSMUST00000049312.14
    Conserved Domains (1) summary
    pfam09788
    Location:4 → 270
    Tmemb_55A; Transmembrane protein 55A

  3. NM_001310506.1 → NP_001297435.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct central region and C-terminus compared to isoform 1.
    Source sequence(s)
    AK144251, BE943635
    Consensus CDS
    CCDS79322.1
    UniProtKB/TrEMBL
    E0CZ18
    Related
    ENSMUSP00000123697.2, ENSMUST00000162957.8
    Conserved Domains (1) summary
    pfam09788
    Location:4 → 154
    Tmemb_55A; Transmembrane protein 55A

  4. NM_001310507.1 → NP_001297436.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct central region and C-terminus compared to isoform 1.
    Source sequence(s)
    AK144251, BE943635, CX240137
    Consensus CDS
    CCDS79323.1
    UniProtKB/TrEMBL
    E0CZF6
    Related
    ENSMUSP00000125414.2, ENSMUST00000161166.8
    Conserved Domains (1) summary
    pfam09788
    Location:4 → 147
    Tmemb_55A; Transmembrane protein 55A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51164672..51168306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TWL2.1 GenPept UniProtKB/Swiss-Prot:Q3TWL2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous