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Khnyn KH and NYN domain containing [ Mus musculus (house mouse) ]

Gene ID: 219094, updated on 2-Nov-2024

Summary

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Official Symbol
Khnynprovided by MGI
Official Full Name
KH and NYN domain containingprovided by MGI
Primary source
MGI:MGI:2451333
See related
Ensembl:ENSMUSG00000047153 AllianceGenome:MGI:2451333
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0323; mKIAA0323; 6330555F21; 9130227C08Rik
Summary
This gene encodes a protein with a C-terminal RNA modifying domain that belongs to a family of ribonucleases typified by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like nucleases (NYN). The NYN domain shares a common protein fold with two other groups of nucleases, the PilT N-terminal nuclease and FLAP nuclease superfamilies. In addition to the NYN domain, the protein encoded by this gene also contains an N-terminal K homology RNA-binding domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in colon adult (RPKM 21.7), cerebellum adult (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Khnyn in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56122269..56136237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55884812..55898780)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene NYN domain and retroviral integrase containing Neighboring gene STARR-positive B cell enhancer ABC_E7318 Neighboring gene STARR-positive B cell enhancer ABC_E7319 Neighboring gene cerebellin 3 precursor protein Neighboring gene short chain dehydrogenase/reductase family 39U, member 1 Neighboring gene STARR-seq mESC enhancer starr_36786 Neighboring gene chymase 1, mast cell Neighboring gene mast cell protease, pseudogene 1 Neighboring gene chymase 2, mast cell

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  4. The NYN domains: novel predicted RNAses with a PIN domain-like fold. Anantharaman V, et al. RNA Biol, 2006 Jan-Mar. PMID 17114934
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein KHNYN
Names
KH and NYN domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027143.3 → NP_081419.1  protein KHNYN

    See identical proteins and their annotated locations for NP_081419.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC098877, AK122247, BP757894
    Consensus CDS
    CCDS27134.1
    UniProtKB/Swiss-Prot
    Q14B94, Q80U38, Q8BGJ6, Q8C082
    UniProtKB/TrEMBL
    A0A2I3BPI4
    Related
    ENSMUSP00000022831.4, ENSMUST00000022831.5
    Conserved Domains (1) summary
    pfam11977
    Location:429 → 582
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RNA

  1. NR_138134.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC098877, BP757894
    Related
    ENSMUST00000228462.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56122269..56136237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003950841.1 RNA Sequence

  2. XR_383164.4 RNA Sequence

  3. XR_004938384.1 RNA Sequence

  4. XR_004938383.1 RNA Sequence

  5. XR_383165.3 RNA Sequence

  6. XR_004938382.1 RNA Sequence

  7. XR_383166.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80U38.2 GenPept UniProtKB/Swiss-Prot:Q80U38

Gene LinkOut

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