FASN fatty acid synthase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FASNprovided by HGNC
Official Full Name: fatty acid synthaseprovided by HGNC
Primary source: HGNC:HGNC:3594
See related: Ensembl:ENSG00000169710 MIM:600212; AllianceGenome:HGNC:3594
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAS; OA-519; SDR27X1
Summary: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Annotation information: Note: FAS (Gene ID: 355) and FASN (Gene ID: 2194) share the FAS symbol/alias in common. FAS is a widely used alternative name for fatty acid synthase (FASN), which can be confused with the official symbol for FAS (Fas cell surface death receptor, GeneID 355). [01 Jun 2018]
Expression: Biased expression in fat (RPKM 227.7), prostate (RPKM 28.4) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (82078338..82098236, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (82945493..82965389, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (80036214..80056112, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis.
Title: The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis.
FAS/SREBP-1c contributes to colorectal carcinogenesis through calcium signaling pathway and cAMP signaling pathway.
Title: FAS/SREBP-1c contributes to colorectal carcinogenesis through calcium signaling pathway and cAMP signaling pathway.
The m[6]A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN.
Title: The m(6)A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN.
FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma.
Title: FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma.
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Title: GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
PITPNC1 Suppress CD8[+] T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
Title: PITPNC1 Suppress CD8(+) T cell immune function and promote radioresistance in rectal cancer by modulating FASN/CD155.
FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer.
Title: FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer.
Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer.
Title: Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer.
Differential Sperm Proteomics Reveals the Significance of Fatty Acid Synthase and Clusterin in Idiopathic Recurrent Pregnancy Loss.
Title: Differential Sperm Proteomics Reveals the Significance of Fatty Acid Synthase and Clusterin in Idiopathic Recurrent Pregnancy Loss.
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Title: Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.

Submit: New GeneRIF Correction See all GeneRIFs (271)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Cellular biotinylated fatty acid synthase protein (FASN) is incorporated into HIV-1 Gag virus-like particles	PubMed
	gag	Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Vif	vif	HIV-1 Vif interacts with FASN	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1256 (e-PCR)
- UniSTS:149801

D17S1571 (e-PCR)
- UniSTS:151862

FASN_7242 (e-PCR)
- UniSTS:466167

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity	IEA Inferred from Electronic Annotation more info
enables (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity	IEA Inferred from Electronic Annotation more info
enables (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity	IEA Inferred from Electronic Annotation more info
enables (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	IEA Inferred from Electronic Annotation more info
enables (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables [acyl-carrier-protein] S-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables [acyl-carrier-protein] S-malonyltransferase activity	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables fatty acid synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-[ACP] hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphopantetheine binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial intestinal barrier	IEA Inferred from Electronic Annotation more info
involved_in ether lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in glandular epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mammary gland development	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral process	IDA Inferred from Direct Assay more info	PubMed
involved_in monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil differentiation	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	HDA more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in glycogen granule	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: fatty acid synthase

Names: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Acyl-[acyl-carrier-protein] hydrolase; Enoyl-[acyl-carrier-protein] reductase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; short chain dehydrogenase/reductase family 27X, member 1; type I fatty acid synthase

NP_004095.4

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

XP_011521840.1

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

XP_054171452.1

EC 1.1.1.100

EC 1.3.1.39

EC 2.3.1.38

EC 2.3.1.39

EC 2.3.1.41

EC 2.3.1.85

EC 3.1.2.14

EC 4.2.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004104.5 → NP_004095.4 fatty acid synthase

See identical proteins and their annotated locations for NP_004095.4

Status: REVIEWED

Source sequence(s)

AC135056, BC007267, BC021544, BC063242

Consensus CDS

CCDS11801.1

UniProtKB/Swiss-Prot

P49327, Q13479, Q16702, Q4LE83, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0

UniProtKB/TrEMBL

A0A0U1RQF0

Related

ENSP00000304592.2, ENST00000306749.4

Conserved Domains (11) summary

cd05195
Location:1566 → 1854

enoyl_red; enoyl reductase of polyketide synthase

cd08954
Location:1876 → 2112

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2111 → 2179

PKS_PP; Phosphopantetheine attachment site

smart00829
Location:1564 → 1854

PKS_ER; Enoylreductase

COG3321
Location:1 → 1022

PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam00698
Location:493 → 810

Acyl_transf_1; Acyl transferase domain

pfam00975
Location:2242 → 2488

Thioesterase; Thioesterase domain

pfam08242
Location:1243 → 1342

Methyltransf_12; Methyltransferase domain

pfam16197
Location:362 → 474

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:874 → 1105

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

82078338..82098236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011523538.3 → XP_011521840.1 fatty acid synthase isoform X1

See identical proteins and their annotated locations for XP_011521840.1

UniProtKB/Swiss-Prot

P49327, Q13479, Q16702, Q4LE83, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0

UniProtKB/TrEMBL

A0A0U1RQF0

Conserved Domains (11) summary

cd05195
Location:1566 → 1854

enoyl_red; enoyl reductase of polyketide synthase

cd08954
Location:1876 → 2112

KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs

smart00823
Location:2111 → 2179

PKS_PP; Phosphopantetheine attachment site

smart00829
Location:1564 → 1854

PKS_ER; Enoylreductase

COG3321
Location:1 → 1022

PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]

cd00833
Location:2 → 404

PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...

pfam00698
Location:493 → 810

Acyl_transf_1; Acyl transferase domain

pfam00975
Location:2242 → 2488

Thioesterase; Thioesterase domain

pfam08242
Location:1243 → 1342

Methyltransf_12; Methyltransferase domain

pfam16197
Location:362 → 474

KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension

cl00509
Location:874 → 1105

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...