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Dedd death effector domain-containing [ Mus musculus (house mouse) ]

Gene ID: 21945, updated on 2-Nov-2024

Summary

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Official Symbol
Deddprovided by MGI
Official Full Name
death effector domain-containingprovided by MGI
Primary source
MGI:MGI:1333874
See related
Ensembl:ENSMUSG00000013973 AllianceGenome:MGI:1333874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DEFT; KE05; FLDED1; Dedpro1; CASP8IP1
Summary
Enables DNA binding activity. Acts upstream of or within decidualization; extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleolus. Is expressed in central nervous system and retina. Orthologous to human DEDD (death effector domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 26.5), large intestine adult (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dedd in Genome Data Viewer
Location:
1 H3; 1 79.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171152229..171170843)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171324661..171342501)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene predicted gene, 25151 Neighboring gene predicted gene, 20045 Neighboring gene STARR-positive B cell enhancer ABC_E2019 Neighboring gene nitrilase 1 Neighboring gene prefoldin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4387 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [Cell cycle and cell sizing regulation via death effector domain]. Kurabe N, et al. Seikagaku, 2009 Jan. PMID 19260450
  2. The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. Kurabe N, et al. Biochem Biophys Res Commun, 2010 Jan 22. PMID 20043882, Free PMC Article
  3. The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. Kurabe N, et al. J Biol Chem, 2009 Feb 20. PMID 19106089, Free PMC Article
  4. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. Stegh AH, et al. EMBO J, 1998 Oct 15. PMID 9774341, Free PMC Article
  5. Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. Arai S, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17283331, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was accompanied by disintegration of implantation site structure, leading to embryonic death before placentation.
    Title: Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice.
  2. DEDD plays an important role in maintenance of the Akt protein level, which in consequence supports the efficient incorporation of glucose into skeletal muscles and adipose tissues.
    Title: The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.
  3. It regulates cell cycle and cell sizing. (review)
    Title: [Cell cycle and cell sizing regulation via death effector domain].
  4. The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.
    Title: The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.
  5. DEDD acts as a novel inhibitor of the mitotic Cdk1/cyclin B1 complex and is an impeder of cell mitosis, and its absence critically influences cell and body size via modulation of rRNA synthesis
    Title: Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within decidualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
death effector domain-containing protein
Names
tumor necrosis factor (ligand) superfamily, member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128609.2 → NP_001122081.1  death effector domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001122081.1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Related
    ENSMUSP00000106931.2, ENSMUST00000111300.8
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD

  2. NM_001357550.2 → NP_001344479.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD

  3. NM_001357551.2 → NP_001344480.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD

  4. NM_001357552.2 → NP_001344481.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD

  5. NM_001357553.2 → NP_001344482.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Related
    ENSMUSP00000095075.2, ENSMUST00000097467.8
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD

  6. NM_001420632.1 → NP_001407561.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001

  7. NM_001420633.1 → NP_001407562.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001

  8. NM_001420634.1 → NP_001407563.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001

  9. NM_001420635.1 → NP_001407564.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001

  10. NM_001420636.1 → NP_001407565.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001

  11. NM_001420637.1 → NP_001407566.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001

  12. NM_001420638.1 → NP_001407567.1  death effector domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001

  13. NM_001420639.1 → NP_001407568.1  death effector domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087229

  14. NM_001420640.1 → NP_001407569.1  death effector domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087229

  15. NM_001420641.1 → NP_001407570.1  death effector domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087229

  16. NM_011615.4 → NP_035745.3  death effector domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_035745.3

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15490.1
    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Related
    ENSMUSP00000068419.5, ENSMUST00000064950.11
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171152229..171170843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496739.4 → XP_006496802.1  death effector domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006496802.1

    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Related
    ENSMUSP00000106930.2, ENSMUST00000111299.8
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD

  2. XM_011238782.2 → XP_011237084.1  death effector domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011237084.1

    UniProtKB/Swiss-Prot
    Q7TQH8, Q9R227, Q9Z1L3
    UniProtKB/TrEMBL
    Q3U001, Q3UYN3
    Conserved Domains (1) summary
    cd08790
    Location:22 → 118
    DED_DEDD; Death Effector Domain of DEDD
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1L3.1 GenPept UniProtKB/Swiss-Prot:Q9Z1L3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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