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Tnni1 troponin I, skeletal, slow 1 [ Mus musculus (house mouse) ]

Gene ID: 21952, updated on 2-Nov-2024

Summary

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Official Symbol
Tnni1provided by MGI
Official Full Name
troponin I, skeletal, slow 1provided by MGI
Primary source
MGI:MGI:105073
See related
Ensembl:ENSMUSG00000026418 AllianceGenome:MGI:105073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ssTnI; 2700018B22Rik
Summary
Predicted to enable actin binding activity. Acts upstream of or within transition between fast and slow fiber and ventricular cardiac muscle tissue morphogenesis. Predicted to be part of troponin complex. Is expressed in several structures, including alimentary system; diaphragm; heart; nervous system; and skeletal musculature. Orthologous to human TNNI1 (troponin I1, slow skeletal type). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 75.2), colon adult (RPKM 20.1) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Tnni1 in Genome Data Viewer
Location:
1 E4; 1 59.28 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135709252..135738727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135783033..135810989)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cysteine and glycine-rich protein 1 Neighboring gene STARR-seq mESC enhancer starr_02385 Neighboring gene predicted gene, 53478 Neighboring gene STARR-positive B cell enhancer ABC_E2561 Neighboring gene STARR-seq mESC enhancer starr_02387 Neighboring gene STARR-seq mESC enhancer starr_02388 Neighboring gene STARR-seq mESC enhancer starr_02389 Neighboring gene pleckstrin homology like domain, family A, member 3 Neighboring gene STARR-seq mESC enhancer starr_02392 Neighboring gene STARR-seq mESC enhancer starr_02394 Neighboring gene ladinin Neighboring gene troponin T2, cardiac

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Thyroid hormone inhibits slow skeletal TnI expression in cardiac TnI-null myocardial cells. Riedel B, et al. Tissue Cell, 2005 Feb. PMID 15695175
  2. Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. Layland J, et al. FASEB J, 2005 Jul. PMID 15855227
  3. DNA methylation regulates mouse cardiac myofibril gene expression during heart development. Xu Y, et al. J Biomed Sci, 2015 Oct 17. PMID 26475623, Free PMC Article
  4. Functional characterization of mouse fetal TnI gene promoters in myocardial cells. Du J, et al. J Biomed Sci, 2008 Sep. PMID 18357515
  5. The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect. Hornos F, et al. J Biol Chem, 2021 Jan-Jun. PMID 33814345, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect.
    Title: The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect.
  2. the up-stream domain ( approximately 1,800 bp) of mouse fetal TnI gene is been cloned and characterized
    Title: Functional characterization of mouse fetal TnI gene promoters in myocardial cells.
  3. Phosphorylation of troponin I was significantly reduced in Galphaq-overexpressing mice compared to wild type.
    Title: Reduced troponin I phosphorylation and increased Ca(2+)-dependent ATP-consumption in triton X-skinned fiber preparations from Galphaq overexpressor mice.
  4. data demonstrate that thyroid hormone can alter the time course of ssTnI gene expression in cultured cardiac myocytes and TnI gene regulation is also controlled by some unknown programmed events inside of cardiac myocytes
    Title: Thyroid hormone inhibits slow skeletal TnI expression in cardiac TnI-null myocardial cells.
  5. K+-depolarization increased Tnni1 and Acta1 mRNA levels in both differentiated C2C12 and rat skeletal muscle cells in primary culture
    Title: Differential gene expression in skeletal muscle cells after membrane depolarization.
  6. a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges
    Title: Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
troponin I, slow skeletal muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112702.1 → NP_001106173.1  troponin I, slow skeletal muscle

    See identical proteins and their annotated locations for NP_001106173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA271187, AK012258, AV124377, CR521220
    Consensus CDS
    CCDS48374.1
    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    F6QC77
    Related
    ENSMUSP00000122925.2, ENSMUST00000154463.8
    Conserved Domains (1) summary
    pfam00992
    Location:15 → 146
    Troponin

  2. NM_021467.5 → NP_067442.1  troponin I, slow skeletal muscle

    See identical proteins and their annotated locations for NP_067442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA230582, AK012258, AV124377, CR521220
    Consensus CDS
    CCDS48374.1
    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    F6QC77
    Related
    ENSMUSP00000121966.2, ENSMUST00000152208.8
    Conserved Domains (1) summary
    pfam00992
    Location:15 → 146
    Troponin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135709252..135738727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163551.1 → XP_036019444.1  troponin I, slow skeletal muscle isoform X1

    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    F6QC77
    Conserved Domains (1) summary
    pfam00992
    Location:15 → 146
    Troponin

  2. XM_011247974.4 → XP_011246276.1  troponin I, slow skeletal muscle isoform X1

    See identical proteins and their annotated locations for XP_011246276.1

    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    F6QC77
    Conserved Domains (1) summary
    pfam00992
    Location:15 → 146
    Troponin

  3. XM_006529382.4 → XP_006529445.1  troponin I, slow skeletal muscle isoform X1

    See identical proteins and their annotated locations for XP_006529445.1

    UniProtKB/Swiss-Prot
    Q9WUZ5
    UniProtKB/TrEMBL
    F6QC77
    Conserved Domains (1) summary
    pfam00992
    Location:15 → 146
    Troponin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUZ5.3 GenPept UniProtKB/Swiss-Prot:Q9WUZ5

Gene LinkOut

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