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YPEL4 yippee like 4 [ Homo sapiens (human) ]

Gene ID: 219539, updated on 2-Nov-2024

Summary

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Official Symbol
YPEL4provided by HGNC
Official Full Name
yippee like 4provided by HGNC
Primary source
HGNC:HGNC:18328
See related
Ensembl:ENSG00000166793 MIM:609725; AllianceGenome:HGNC:18328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including negative regulation of erythrocyte clearance; negative regulation of erythrocyte differentiation; and protein localization to plasma membrane. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 4.8), bone marrow (RPKM 3.2) and 12 other tissues See more
Orthologs
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Genomic context

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See YPEL4 in Genome Data Viewer
Location:
11q12.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57645087..57649912, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57595261..57603883, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57412560..57417385, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene serpin family G member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3353 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57406889-57407468 Neighboring gene MIR130A host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57410743-57411242 Neighboring gene microRNA 130a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4727 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57435387-57436026 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57436027-57436664 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter. Oki K, et al. Mol Cell Endocrinol, 2016 Oct 15. PMID 27333825, Free PMC Article
  2. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. Liang P, et al. Biochem Cell Biol, 2010 Jun. PMID 20555386
  3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2011 Jan. PMID 20508983, Free PMC Article
  5. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrated that YPEL4 stimulates human adrenal cortical cell proliferation, increasing aldosterone production. Also, YPEL4 expression levels are higher in human aldosterone producing adenoma.
    Title: YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter.
  2. Data show that major vault protein (MVP), a lung resistance associated protein, is a binding partner of YPEL4.
    Title: MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • FLJ30213, MGC102723, MGC138324

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein yippee-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363487.2 → NP_001350416.1  protein yippee-like 4

    Status: VALIDATED

    Source sequence(s)
    AP000662
    Consensus CDS
    CCDS7963.1
    UniProtKB/Swiss-Prot
    B3KW92, Q2M3U7, Q65Z98, Q96NS1
    UniProtKB/TrEMBL
    B3KNT4
    Conserved Domains (1) summary
    cl13152
    Location:28 → 118
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. NM_145008.3 → NP_659445.1  protein yippee-like 4

    See identical proteins and their annotated locations for NP_659445.1

    Status: VALIDATED

    Source sequence(s)
    AB098738
    Consensus CDS
    CCDS7963.1
    UniProtKB/Swiss-Prot
    B3KW92, Q2M3U7, Q65Z98, Q96NS1
    UniProtKB/TrEMBL
    B3KNT4
    Related
    ENSP00000300022.3, ENST00000300022.8
    Conserved Domains (1) summary
    cl13152
    Location:28 → 118
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57645087..57649912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426531.1 → XP_047282487.1  protein yippee-like 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KW92, Q2M3U7, Q65Z98, Q96NS1
    Related
    ENSP00000432648.1, ENST00000524669.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57595261..57603883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367978.1 → XP_054223953.1  protein yippee-like 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KW92, Q2M3U7, Q65Z98, Q96NS1

  2. XM_054367977.1 → XP_054223952.1  protein yippee-like 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96NS1.1 GenPept UniProtKB/Swiss-Prot:Q96NS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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