FOLH1B folate hydrolase 1B (pseudogene) [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOLH1Bprovided by HGNC
Official Full Name: folate hydrolase 1B (pseudogene)provided by HGNC
Primary source: HGNC:HGNC:13636
See related: MIM:609020; AllianceGenome:HGNC:13636
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PSM; FOLH2; FOLHP; PSMAL; PSMA-LIKE
Summary: Enables metallocarboxypeptidase activity. Involved in C-terminal protein deglutamylation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum (RPKM 38.8), prostate (RPKM 20.3) and 6 other tissues See more
Orthologs: all
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Genomic context

Location:: 11q14.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (89659268..89698718)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (89578945..89618403)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (89370637..89431886)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH71396 (e-PCR)
- UniSTS:89606

RH69652 (e-PCR)
- UniSTS:88408

Other Names

N-acetylated-alpha-linked-acidic dipeptidase
cell growth-inhibiting gene 26 protein
folate hydrolase 2
prostate-specific membrane antigen-like protein
putative N-acetylated-alpha-linked acidic dipeptidase
putative folate hydrolase 1B

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in C-terminal protein deglutamylation	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_175944.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AP003122

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

89659268..89698718

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

89578945..89618403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_003258.2: Suppressed sequence

Description

NG_003258.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
NM_001395847.1: Suppressed sequence

Description

NM_001395847.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
NM_153696.3: Suppressed sequence

Description

NM_153696.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.