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Traf5 TNF receptor-associated factor 5 [ Mus musculus (house mouse) ]

Gene ID: 22033, updated on 17-Aug-2024

Summary

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Official Symbol
Traf5provided by MGI
Official Full Name
TNF receptor-associated factor 5provided by MGI
Primary source
MGI:MGI:107548
See related
Ensembl:ENSMUSG00000026637 AllianceGenome:MGI:107548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable enzyme binding activity; identical protein binding activity; and tumor necrosis factor receptor binding activity. Involved in interleukin-17-mediated signaling pathway and regulation of gene expression. Acts upstream of or within positive regulation of cell population proliferation and signal transduction. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in genitourinary system and tongue muscle. Orthologous to human TRAF5 (TNF receptor associated factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 10.1), bladder adult (RPKM 8.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H6; 1 97.11 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191729164..191776899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191997203..192092599, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03447 Neighboring gene predicted gene, 39743 Neighboring gene retinal degeneration 3 Neighboring gene STARR-positive B cell enhancer ABC_E4410 Neighboring gene predicted gene, 32460 Neighboring gene microRNA 3473c Neighboring gene glutathione S-transferase, pi, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11114 Neighboring gene STARR-positive B cell enhancer ABC_E11115 Neighboring gene REST corepressor 3 Neighboring gene predicted gene 10516 Neighboring gene predicted gene, 39745

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes. Kawahara E, et al. J Immunol, 2022 Feb 1. PMID 34996840
  2. Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Gissler MC, et al. Arterioscler Thromb Vasc Biol, 2021 Oct. PMID 34348490
  3. TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells. Phung HT, et al. Immunohorizons, 2020 Mar 10. PMID 32156688
  4. Tumor Necrosis Factor Receptor-Associated Factor 5 Promotes Arterial Neointima Formation through Smooth Muscle Cell Proliferation. Willecke F, et al. J Vasc Res, 2019. PMID 31437850
  5. Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-κB activation. Wu F, et al. Int J Mol Med, 2018 Jan. PMID 29115406

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARgamma.
    Title: Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARγ.
  2. TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice.
    Title: TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice.
  3. TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes.
    Title: TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes.
  4. Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice.
    Title: Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice.
  5. TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells.
    Title: TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells.
  6. TRAF5 deficiency mitigates neointima formation in mice, likely through a TRAF5-dependent decrease in vascular smooth muscle cell proliferation.
    Title: Tumor Necrosis Factor Receptor-Associated Factor 5 Promotes Arterial Neointima Formation through Smooth Muscle Cell Proliferation.
  7. The results demonstrate that gp130-associated TRAF2 and TRAF5 inhibit the interaction between two JAK proteins in the IL-6R complex that is essential for initiating the JAK-STAT signaling pathway.
    Title: TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction.
  8. TRAF5 is crucially involved in OSM-mediated lung inflammation probably by inducing lung stromal/fibroblast cell activation.
    Title: TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation.
  9. our data indicate that Berberine exerts protective effects against chronic renal failurepartly through the TRAF5-mediated activation of the NF-kappaB signaling pathway in mouse podocytes
    Title: Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-κB activation.
  10. this study shows that TRAF2 and TRAF5 work as important regulators of the IL-6R signaling needed for Th17 development
    Title: TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioesterase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
  
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction involved in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TNF receptor-associated factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011633.2 → NP_035763.2  TNF receptor-associated factor 5

    See identical proteins and their annotated locations for NP_035763.2

    Status: VALIDATED

    Source sequence(s)
    AK144694, BE691772, BY290436
    UniProtKB/Swiss-Prot
    P70191, Q61480
    UniProtKB/TrEMBL
    Q3UMS9
    Related
    ENSMUSP00000141931.3, ENSMUST00000195815.3
    Conserved Domains (5) summary
    COG1196
    Location:237 → 419
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03780
    Location:404 → 551
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:128 → 183
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl40617
    Location:185 → 241
    zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191729164..191776899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163631.1 → XP_036019524.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/Swiss-Prot
    P70191, Q61480
    UniProtKB/TrEMBL
    Q3UMS9
    Conserved Domains (5) summary
    COG1196
    Location:237 → 419
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03780
    Location:404 → 551
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:128 → 183
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl40617
    Location:185 → 241
    zf-TRAF; TRAF-type zinc finger

  2. XM_036163634.1 → XP_036019527.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/Swiss-Prot
    P70191, Q61480
    UniProtKB/TrEMBL
    Q3UMS9
    Conserved Domains (5) summary
    COG1196
    Location:237 → 419
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03780
    Location:404 → 551
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:128 → 183
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl40617
    Location:185 → 241
    zf-TRAF; TRAF-type zinc finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70191.1 GenPept UniProtKB/Swiss-Prot:P70191

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials