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FCER2 Fc epsilon receptor II [ Homo sapiens (human) ]

Gene ID: 2208, updated on 2-Nov-2024

Summary

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Official Symbol
FCER2provided by HGNC
Official Full Name
Fc epsilon receptor IIprovided by HGNC
Primary source
HGNC:HGNC:3612
See related
Ensembl:ENSG00000104921 MIM:151445; AllianceGenome:HGNC:3612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD23; FCE2; CD23A; IGEBF; CLEC4J; FCErII; BLAST-2
Summary
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Expression
Biased expression in spleen (RPKM 20.9), lymph node (RPKM 16.3) and 4 other tissues See more
Orthologs
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Genomic context

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See FCER2 in Genome Data Viewer
Location:
19p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7688776..7702131, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7689661..7703156, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7753662..7767017, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9990 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene Sharpr-MPRA regulatory region 435 Neighboring gene trafficking protein particle complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:7749795-7749977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13897 Neighboring gene uncharacterized LOC105372262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7785915-7786414 Neighboring gene CLEC4G promoter region Neighboring gene C-type lectin domain family 4 member G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The CD23a and CD23b proximal promoters display different sensitivities to exogenous stimuli in B lymphocytes. Ewart MA, et al. Genes Immun, 2002 May. PMID 12070780
  2. CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage. Chan MA, et al. Clin Immunol, 2010 Dec. PMID 20805040
  3. CD23/FcεRII: molecular multi-tasking. Acharya M, et al. Clin Exp Immunol, 2010 Oct. PMID 20831712, Free PMC Article
  4. CD23-bound IgE augments and dominates recall responses through human naive B cells. Griffith QK, et al. J Immunol, 2011 Jan 15. PMID 21160045
  5. CD23-dependent transcytosis of IgE and immune complex across the polarized human respiratory epithelial cells. Palaniyandi S, et al. J Immunol, 2011 Mar 15. PMID 21307287

See all (149) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of CD23 Activated ERK Signaling Pathway in the Pathogenesis of Eosinophilic Chronic Sinusitis with Nasal Polyps.
    Title: Role of CD23 Activated ERK Signaling Pathway in the Pathogenesis of Eosinophilic Chronic Sinusitis with Nasal Polyps.
  2. IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
    Title: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
  3. An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing.
    Title: An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing.
  4. Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
    Title: Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
  5. Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.
    Title: Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.
  6. Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction.
    Title: Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction.
  7. Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma.
    Title: Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma.
  8. CD23 mediated the induction of pro-inflammatory cytokines Interleukin-1 beta and tumor necrosis factors-alpha in Aspergillus fumigatus keratitis.
    Title: CD23 mediated the induction of pro-inflammatory cytokines Interleukin-1 beta and tumor necrosis factors-alpha in Aspergillus fumigatus keratitis.
  9. Human DC-SIGN and CD23 do not interact with human IgG.
    Title: Human DC-SIGN and CD23 do not interact with human IgG.
  10. FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.
    Title: FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.
Submit: New GeneRIF Correction See all GeneRIFs (103)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Fc fragment of IgE, low affinity receptor II (FCER2; CD23) in human B cells PubMed
env CD23 protein membrane expression is upregulated by HIV-1 gp120 and this upregulation induces the production of nitric oxide (NO) and IL-1beta PubMed
Envelope surface glycoprotein gp160, precursor env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
Nef nef In macrophages, activation of CD40 or expression of HIV-1 Nef induces the release of sCD23 and sICAM, which mediate effects on T lymphocytes, rendering them permissive to HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding TAS
Traceable Author Statement
more info
 PubMed 
enables low-affinity IgE receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell antigen processing and presentation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Fc receptor-mediated immune complex endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Fc-epsilon receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macrophage activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of killing of cells of another organism IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
low affinity immunoglobulin epsilon Fc receptor
Names
C-type lectin domain family 4, member J
CD23 antigen
Fc fragment of IgE receptor II
Fc fragment of IgE, low affinity II, receptor for (CD23)
FcepsilonRII
fc-epsilon-RII
immunoglobulin E-binding factor
immunoglobulin epsilon-chain
lymphocyte IgE receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029554.1 RefSeqGene

    Range
    5016..18371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207019.3 → NP_001193948.2  low affinity immunoglobulin epsilon Fc receptor isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b, also known as CD23b) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by data in PubMed IDs 12379312 and 15843555.
    Source sequence(s)
    AC008763, BC014108
    UniProtKB/TrEMBL
    K3W4U1
    Related
    ENSP00000353178.4, ENST00000360067.8
    Conserved Domains (2) summary
    smart00034
    Location:162 → 281
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl23720
    Location:76 → 152
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_001220500.2 → NP_001207429.1  low affinity immunoglobulin epsilon Fc receptor isoform a

    See identical proteins and their annotated locations for NP_001207429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a, also known as CD23a).
    Source sequence(s)
    BC062591, DA957269
    Consensus CDS
    CCDS12184.1
    UniProtKB/Swiss-Prot
    P06734
    Related
    ENSP00000471974.1, ENST00000597921.6
    Conserved Domains (2) summary
    smart00034
    Location:163 → 282
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl23720
    Location:77 → 153
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. NM_002002.5 → NP_001993.2  low affinity immunoglobulin epsilon Fc receptor isoform a

    See identical proteins and their annotated locations for NP_001993.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a, also known as CD23a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    BC014108, DA957269
    Consensus CDS
    CCDS12184.1
    UniProtKB/Swiss-Prot
    P06734
    Related
    ENSP00000264072.6, ENST00000346664.9
    Conserved Domains (2) summary
    smart00034
    Location:163 → 282
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl23720
    Location:77 → 153
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7688776..7702131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272462.5 → XP_005272519.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

    See identical proteins and their annotated locations for XP_005272519.1

    UniProtKB/Swiss-Prot
    P06734
    Conserved Domains (2) summary
    smart00034
    Location:163 → 282
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    cl23720
    Location:77 → 153
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7689661..7703156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320198.1 → XP_054176173.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

    UniProtKB/Swiss-Prot
    P06734
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06734.1 GenPept UniProtKB/Swiss-Prot:P06734

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