Gfus GDP-L-fucose synthase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gfusprovided by MGI
Official Full Name: GDP-L-fucose synthaseprovided by MGI
Primary source: MGI:MGI:98857
See related: Ensembl:ENSMUSG00000022570 AllianceGenome:MGI:98857
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FX; Tsta3; Tstap35b
Summary: Enables GDP-L-fucose synthase activity and isomerase activity. Involved in 'de novo' GDP-L-fucose biosynthetic process. Acts upstream of or within T cell mediated cytotoxicity. Is active in cytosol. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 74.6), large intestine adult (RPKM 59.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.1 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75796532..75801613, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (75924669..75929821, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fucosylation-modified Notch receptor may represent a novel extrinsic regulator for hematopoietic stem cells (HSC) engraftment and HSC niche maintenance.
Title: Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP-L-fucose synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP-L-fucose synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables GDP-L-fucose synthase activity	IEA Inferred from Electronic Annotation more info
enables GDP-L-fucose synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GDP-L-fucose synthase activity	ISO Inferred from Sequence Orthology more info
enables GDP-mannose 3,5-epimerase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' GDP-L-fucose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 'de novo' GDP-L-fucose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GDP-mannose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GDP-L-fucose synthase

Names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; GDP-L-fucose synthetase; GDP-fucose synthase; protein FX; red cell NADP(H)-binding protein; tissue specific transplantation antigen P35B; transplantation antigen P35B; tum-P35B antigen

NP_001343934.1

EC 1.1.1.271

NP_001398744.1

EC 1.1.1.271

NP_001398745.1

EC 1.1.1.271

NP_112478.1

EC 1.1.1.271

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357005.2 → NP_001343934.1 GDP-L-fucose synthase isoform 1

Status: VALIDATED

Source sequence(s)

AC116520

Consensus CDS

CCDS27555.1

UniProtKB/Swiss-Prot

P23591

UniProtKB/TrEMBL

A0A2R8VHD0, Q5HZI6

Related

ENSMUSP00000155139.2, ENSMUST00000229641.2

Conserved Domains (1) summary

cd05239
Location:9 → 312

GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
NM_001411815.1 → NP_001398744.1 GDP-L-fucose synthase isoform 2

Status: VALIDATED

Source sequence(s)

AC116520

UniProtKB/TrEMBL

A0A2R8VI39
NM_001411816.1 → NP_001398745.1 GDP-L-fucose synthase isoform 2

Status: VALIDATED

Source sequence(s)

AC116520

UniProtKB/TrEMBL

A0A2R8VI39

Related

ENSMUSP00000155711.2, ENSMUST00000229951.2
NM_031201.2 → NP_112478.1 GDP-L-fucose synthase isoform 1

See identical proteins and their annotated locations for NP_112478.1

Status: VALIDATED

Source sequence(s)

AC116520

Consensus CDS

CCDS27555.1

UniProtKB/Swiss-Prot

P23591

UniProtKB/TrEMBL

A0A2R8VHD0, Q5HZI6

Related

ENSMUSP00000023231.6, ENSMUST00000023231.7

Conserved Domains (1) summary

cd05239
Location:9 → 312

GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

RNA

NR_177931.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520

Related

ENSMUST00000229085.2
NR_177932.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520
NR_177933.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520
NR_177934.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520
NR_177935.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520
NR_177936.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520
NR_177937.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520
NR_177938.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116520

Related

ENSMUST00000230364.2