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Tyrobp TYRO protein tyrosine kinase binding protein [ Mus musculus (house mouse) ]

Gene ID: 22177, updated on 28-Oct-2024

Summary

Official Symbol
Tyrobpprovided by MGI
Official Full Name
TYRO protein tyrosine kinase binding proteinprovided by MGI
Primary source
MGI:MGI:1277211
See related
Ensembl:ENSMUSG00000030579 AllianceGenome:MGI:1277211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly83; DAP12; KARAP
Summary
Enables signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Acts upstream of or within osteoclast differentiation and regulation of osteoclast development. Located in cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in spleen adult (RPKM 223.3), lung adult (RPKM 120.3) and 21 other tissues See more
Orthologs
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Genomic context

See Tyrobp in Genome Data Viewer
Location:
7 B1; 7 17.45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30113207..30117007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30413782..30417582)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42376 Neighboring gene predicted gene, 32029 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31204808-31204961 Neighboring gene STARR-positive B cell enhancer ABC_E8837 Neighboring gene hematopoietic cell signal transducer Neighboring gene STARR-positive B cell enhancer ABC_E4916 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in forebrain development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microglial cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myeloid leukocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transforming growth factor beta1 production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transforming growth factor beta1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of macrophage fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microglial cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of microglial cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of natural killer cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoclast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of osteoclast development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in stimulatory C-type lectin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stimulatory killer cell immunoglobulin-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in stimulatory killer cell immunoglobulin-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TYRO protein tyrosine kinase-binding protein
Names
DNAX-activation protein 12
KAR-associated protein
killer cell activating receptor associated protein
killer-activating receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011662.3NP_035792.1  TYRO protein tyrosine kinase-binding protein precursor

    See identical proteins and their annotated locations for NP_035792.1

    Status: VALIDATED

    Source sequence(s)
    AA242315, BC056450
    Consensus CDS
    CCDS21089.1
    UniProtKB/Swiss-Prot
    O54885, O88603
    UniProtKB/TrEMBL
    A0A140LHP7, Q3U419
    Related
    ENSMUSP00000032800.10, ENSMUST00000032800.10
    Conserved Domains (1) summary
    pfam07213
    Location:2272
    DAP10; DAP10 membrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30113207..30117007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)