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ZSCAN25 zinc finger and SCAN domain containing 25 [ Homo sapiens (human) ]

Gene ID: 221785, updated on 5-Mar-2024

Summary

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Official Symbol
ZSCAN25provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 25provided by HGNC
Primary source
HGNC:HGNC:21961
See related
Ensembl:ENSG00000197037 AllianceGenome:HGNC:21961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF498
Summary
This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 5.1), duodenum (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ZSCAN25 in Genome Data Viewer
Location:
7q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99616946..99738035)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100851926..100993657)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99214569..99270165)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26326 Neighboring gene zinc finger protein 655 Neighboring gene transmembrane protein 225B Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99213715-99214694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99227460-99228106 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99236540-99236705 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene CYP3A5 promoter Neighboring gene cytochrome P450 family 3 subfamily A member 51, pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene CYP3A7 5' regulatory region Neighboring gene enhancer in intron 10 of CYP3A4 Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 Neighboring gene cytochrome P450 family 3 subfamily A member 4 Neighboring gene CYP3A4 5' regulatory region

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation. Zhang X, et al. J Exp Clin Cancer Res, 2022 Feb 28. PMID 35227287, Free PMC Article
  2. Sequence diversity and haplotype structure at the human CYP3A cluster. Thompson EE, et al. Pharmacogenomics J, 2006 Mar-Apr. PMID 16314882
  3. Zinc finger proteins: new insights into structural and functional diversity. Laity JH, et al. Curr Opin Struct Biol, 2001 Feb. PMID 11179890
  4. NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA. Wei X, et al. PLoS Pathog, 2019 Nov. PMID 31751430, Free PMC Article
  5. An atlas of genetic influences on human blood metabolites. Shin SY, et al. Nat Genet, 2014 Jun. PMID 24816252, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome.
    Title: ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome.
  2. ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation.
    Title: ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 25
Names
zinc finger protein 498

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350979.2 → NP_001337908.1  zinc finger and SCAN domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longest isoform (a).
    Source sequence(s)
    AC005020
    Consensus CDS
    CCDS5671.2
    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
    Related
    ENSP00000334800.3, ENST00000334715.7
    Conserved Domains (4) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:324 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:38 → 136
    SCAN; SCAN oligomerization domain

  2. NM_001350980.2 → NP_001337909.1  zinc finger and SCAN domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longest isoform (a).
    Source sequence(s)
    AC005020
    Consensus CDS
    CCDS5671.2
    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
    Conserved Domains (4) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:324 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:38 → 136
    SCAN; SCAN oligomerization domain

  3. NM_001350981.2 → NP_001337910.1  zinc finger and SCAN domain-containing protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform b.
    Source sequence(s)
    AC005020
    UniProtKB/TrEMBL
    B3KPY4
    Conserved Domains (4) summary
    cd07765
    Location:67 → 95
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:160 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:336 → 361
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001350982.2 → NP_001337911.1  zinc finger and SCAN domain-containing protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform b.
    Source sequence(s)
    AC005020
    UniProtKB/TrEMBL
    B3KPY4
    Conserved Domains (4) summary
    cd07765
    Location:67 → 95
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:160 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:336 → 361
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001350983.2 → NP_001337912.1  zinc finger and SCAN domain-containing protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform b.
    Source sequence(s)
    AC005020
    UniProtKB/TrEMBL
    B3KPY4
    Conserved Domains (4) summary
    cd07765
    Location:67 → 95
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:160 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:336 → 361
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001350984.2 → NP_001337913.1  zinc finger and SCAN domain-containing protein 25 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 8, represents the longest transcript and encodes isoform c.
    Source sequence(s)
    AC005020
    Conserved Domains (2) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:38 → 123
    SCAN; SCAN domain

  7. NM_001350985.2 → NP_001337914.1  zinc finger and SCAN domain-containing protein 25 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AC005020
    Conserved Domains (2) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:38 → 123
    SCAN; SCAN domain

  8. NM_001350986.2 → NP_001337915.1  zinc finger and SCAN domain-containing protein 25 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC005020
    Conserved Domains (1) summary
    pfam02023
    Location:38 → 123
    SCAN; SCAN domain

  9. NM_145115.3 → NP_660090.2  zinc finger and SCAN domain-containing protein 25 isoform a

    See identical proteins and their annotated locations for NP_660090.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2 and 3, encodes the longest isoform (a).
    Source sequence(s)
    AC005020, AW195325, BX648158
    Consensus CDS
    CCDS5671.2
    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
    Related
    ENSP00000377708.2, ENST00000394152.7
    Conserved Domains (4) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:324 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:38 → 136
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99616946..99738035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420018.1 → XP_047275974.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  2. XM_047420016.1 → XP_047275972.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  3. XM_011515909.3 → XP_011514211.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    Conserved Domains (2) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:38 → 123
    SCAN; SCAN domain

  4. XM_047420019.1 → XP_047275975.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  5. XM_047420017.1 → XP_047275973.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  6. XM_011515910.3 → XP_011514212.1  zinc finger and SCAN domain-containing protein 25 isoform X3

    Conserved Domains (2) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:38 → 123
    SCAN; SCAN domain

  7. XM_047420020.1 → XP_047275976.1  zinc finger and SCAN domain-containing protein 25 isoform X3

  8. XM_047420011.1 → XP_047275967.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  9. XM_047420014.1 → XP_047275970.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  10. XM_011515907.3 → XP_011514209.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011514209.1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
    Conserved Domains (4) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:324 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:38 → 136
    SCAN; SCAN oligomerization domain

  11. XM_047420013.1 → XP_047275969.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  12. XM_047420015.1 → XP_047275971.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  13. XM_011515905.3 → XP_011514207.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011514207.1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
    Conserved Domains (4) summary
    cd07765
    Location:231 → 259
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:324 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:38 → 136
    SCAN; SCAN oligomerization domain

  14. XM_047420012.1 → XP_047275968.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

RNA

  1. XR_927402.3 RNA Sequence

  2. XR_007059989.1 RNA Sequence

  3. XR_007059990.1 RNA Sequence

  4. XR_007059988.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100851926..100993657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357521.1 → XP_054213496.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  2. XM_054357525.1 → XP_054213500.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  3. XM_054357524.1 → XP_054213499.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  4. XM_054357529.1 → XP_054213504.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  5. XM_054357526.1 → XP_054213501.1  zinc finger and SCAN domain-containing protein 25 isoform X2

  6. XM_054357527.1 → XP_054213502.1  zinc finger and SCAN domain-containing protein 25 isoform X3

  7. XM_054357530.1 → XP_054213505.1  zinc finger and SCAN domain-containing protein 25 isoform X3

  8. XM_054357522.1 → XP_054213497.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  9. XM_054357518.1 → XP_054213493.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  10. XM_054357520.1 → XP_054213495.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  11. XM_054357523.1 → XP_054213498.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  12. XM_054357517.1 → XP_054213492.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  13. XM_054357519.1 → XP_054213494.1  zinc finger and SCAN domain-containing protein 25 isoform X1

    UniProtKB/Swiss-Prot
    A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

  14. XM_054357528.1 → XP_054213503.1  zinc finger and SCAN domain-containing protein 25 isoform X2

RNA

  1. XR_008487539.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSZ9.3 GenPept UniProtKB/Swiss-Prot:Q6NSZ9

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