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Ube2m ubiquitin-conjugating enzyme E2M [ Mus musculus (house mouse) ]

Gene ID: 22192, updated on 18-Sep-2024

Summary

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Official Symbol
Ube2mprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Mprovided by MGI
Primary source
MGI:MGI:108278
See related
Ensembl:ENSMUSG00000005575 AllianceGenome:MGI:108278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBC12; Ubc-rs2; 2510040H03Rik
Summary
Predicted to enable NEDD8 transferase activity and ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of neuron apoptotic process and protein neddylation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human UBE2M (ubiquitin conjugating enzyme E2 M). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 97.2), whole brain E14.5 (RPKM 66.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube2m in Genome Data Viewer
Location:
7 A1; 7 7.73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12769047..12772202, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13035120..13038275, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6512 Neighboring gene predicted gene, 31649 Neighboring gene tripartite motif-containing 28 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13619992-13620293 Neighboring gene charged multivesicular body protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E6513 Neighboring gene myeloid zinc finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E2223 Neighboring gene STARR-seq mESC enhancer starr_18069 Neighboring gene vomeronasal 1 receptor 85

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Wu D, et al. Nat Commun, 2022 May 31. PMID 35641500, Free PMC Article
  2. Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2. McCormack RM, et al. Elife, 2015 Sep 29. PMID 26418746, Free PMC Article
  3. Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition. Vogl AM, et al. Nat Neurosci, 2015 Feb. PMID 25581363
  4. Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice. Pawlowski TL, et al. Genomics, 2009 Sep. PMID 19501643, Free PMC Article
  5. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. Kim AY, et al. J Biol Chem, 2008 Nov 28. PMID 18826954, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
    Title: UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
  2. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.
    Title: The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.
  3. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
    Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (3) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25453, MGC37197

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NEDD8 transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NEDD8 transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynapse assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
NEDD8-conjugating enzyme Ubc12
Names
NEDD8 carrier protein
NEDD8 protein ligase
UBC12 homolog, yeast
ubiquitin C, related sequence 2
NP_001161941.1
NP_001230897.1
NP_663553.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168469.2 → NP_001161941.1  NEDD8-conjugating enzyme Ubc12 isoform 2

    See identical proteins and their annotated locations for NP_001161941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121301
    Consensus CDS
    CCDS52024.1
    UniProtKB/TrEMBL
    G5E919
    Related
    ENSMUSP00000132604.3, ENSMUST00000165394.9
    Conserved Domains (1) summary
    pfam00179
    Location:2 → 71
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_001243968.1 → NP_001230897.1  NEDD8-conjugating enzyme Ubc12 isoform 3

    See identical proteins and their annotated locations for NP_001230897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121301
    UniProtKB/TrEMBL
    F7CDT0
    Related
    ENSMUSP00000122638.2, ENSMUST00000125964.8
    Conserved Domains (1) summary
    pfam00179
    Location:7 → 138
    UQ_con; Ubiquitin-conjugating enzyme

  3. NM_145578.3 → NP_663553.1  NEDD8-conjugating enzyme Ubc12 isoform 1

    See identical proteins and their annotated locations for NP_663553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC121301
    Consensus CDS
    CCDS20825.1
    UniProtKB/Swiss-Prot
    P61082
    UniProtKB/TrEMBL
    F7CDT0
    Related
    ENSMUSP00000005714.8, ENSMUST00000005714.14
    Conserved Domains (1) summary
    pfam00179
    Location:33 → 168
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12769047..12772202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61082.1 GenPept UniProtKB/Swiss-Prot:P61082

Gene LinkOut

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