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PRR15 proline rich 15 [ Homo sapiens (human) ]

Gene ID: 222171, updated on 5-Mar-2024

Summary

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Official Symbol
PRR15provided by HGNC
Official Full Name
proline rich 15provided by HGNC
Primary source
HGNC:HGNC:22310
See related
Ensembl:ENSG00000176532 MIM:618344; AllianceGenome:HGNC:22310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in colon (RPKM 29.0), small intestine (RPKM 15.6) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7p14.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (29563835..29567295)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29701617..29705075)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29603451..29606911)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chimerin 2 Neighboring gene Nanog homeobox pseudogene 4 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:29327971-29328748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29343002-29343502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29343503-29344003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29349448-29350016 Neighboring gene NANOG hESC enhancer GRCh37_chr7:29364906-29365431 Neighboring gene MPRA-validated peak6458 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29414107-29414613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29456733-29457232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29456231-29456732 Neighboring gene PRR15 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29605074-29605937 Neighboring gene GTF3C6 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 12919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29688411-29689013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29689014-29689615 Neighboring gene TMSB4X pseudogene 3 Neighboring gene uncharacterized LOC646762 Neighboring gene microRNA 550a-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect of proline rich 15-deficiency on trophoblast viability and survival. Gates KC, et al. PLoS One, 2017. PMID 28380025, Free PMC Article
  2. Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. Meunier D, et al. Mol Carcinog, 2011 Jan. PMID 21061267
  3. PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer. Guo F, et al. Cell Death Dis, 2023 Apr 18. PMID 37072408, Free PMC Article
  4. The involvement of proline-rich 15 in early conceptus development in sheep. Purcell SH, et al. Biol Reprod, 2009 Dec. PMID 19605793, Free PMC Article
  5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. Teixeira FR, et al. J Biol Chem, 2013 Sep 27. PMID 23940030, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer.
    Title: PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer.
  2. enhances trophoblast viability and survival during early implantation and placentation
    Title: Effect of proline rich 15-deficiency on trophoblast viability and survival.
  3. Proline-rich 15 is required for conceptus elongation and survival during early ovine pregnancy.
    Title: The involvement of proline-rich 15 in early conceptus development in sheep.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
proline-rich protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329996.2 → NP_001316925.1  proline-rich protein 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC007255
    Consensus CDS
    CCDS5421.1
    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13 → 109
    ATAD4; ATPase family AAA domain containing 4

  2. NM_001329997.1 → NP_001316926.1  proline-rich protein 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC007255
    Consensus CDS
    CCDS5421.1
    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13 → 109
    ATAD4; ATPase family AAA domain containing 4

  3. NM_175887.3 → NP_787083.1  proline-rich protein 15

    See identical proteins and their annotated locations for NP_787083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC029131
    Consensus CDS
    CCDS5421.1
    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Related
    ENSP00000317836.2, ENST00000319694.3
    Conserved Domains (1) summary
    pfam15321
    Location:13 → 109
    ATAD4; ATPase family AAA domain containing 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    29563835..29567295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515199.2 → XP_011513501.1  proline-rich protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011513501.1

    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13 → 109
    ATAD4; ATPase family AAA domain containing 4

  2. XM_011515198.2 → XP_011513500.1  proline-rich protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011513500.1

    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13 → 109
    ATAD4; ATPase family AAA domain containing 4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    29701617..29705075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357569.1 → XP_054213544.1  proline-rich protein 15 isoform X1

  2. XM_054357568.1 → XP_054213543.1  proline-rich protein 15 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IV56.1 GenPept UniProtKB/Swiss-Prot:Q8IV56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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