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Ugcg UDP-glucose ceramide glucosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 22234, updated on 28-Oct-2024

Summary

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Official Symbol
Ugcgprovided by MGI
Official Full Name
UDP-glucose ceramide glucosyltransferaseprovided by MGI
Primary source
MGI:MGI:1332243
See related
Ensembl:ENSMUSG00000028381 AllianceGenome:MGI:1332243
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ugcgl; Epcs21; GlcT-1
Summary
Enables ceramide glucosyltransferase activity. Involved in several processes, including cornified envelope assembly; establishment of skin barrier; and glucosylceramide biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in membrane. Is expressed in several structures, including blastocyst; brain; early embryo; liver; and oocyte. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 20.2), whole brain E14.5 (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ugcg in Genome Data Viewer
Location:
4 32.44 cM; 4 B3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59189452..59222833)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59189507..59222833)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene shortage in chiasmata 1 Neighboring gene predicted gene, 35527 Neighboring gene ribosomal protein SA, pseudogene 11 Neighboring gene STARR-seq mESC enhancer starr_10368 Neighboring gene STARR-seq mESC enhancer starr_10369 Neighboring gene STARR-positive B cell enhancer mm9_chr4:59212266-59212567 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59218694-59218997 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59219045-59219154 Neighboring gene STARR-seq mESC enhancer starr_10370 Neighboring gene STARR-positive B cell enhancer ABC_E1031 Neighboring gene STARR-positive B cell enhancer ABC_E9084 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59274266-59274419 Neighboring gene STARR-seq mESC enhancer starr_10371 Neighboring gene STARR-positive B cell enhancer mm9_chr4:59288450-59288750 Neighboring gene predicted gene 12596 Neighboring gene predicted gene, 35578

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of the mouse ceramide glucosyltransferase gene. Ichikawa S, et al. Biochem Biophys Res Commun, 1998 Dec 30. PMID 9918791
  2. [Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth]. Jennemann R, et al. Verh Dtsch Ges Pathol, 2006. PMID 17867597
  3. Ceramides and glucosylceramides are independent antagonists of insulin signaling. Chavez JA, et al. J Biol Chem, 2014 Jan 10. PMID 24214972, Free PMC Article
  4. Glycosphingolipid synthesis in cerebellar Purkinje neurons: roles in myelin formation and axonal homeostasis. Watanabe S, et al. Glia, 2010 Aug. PMID 20544855
  5. Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis. Yamashita T, et al. Biochim Biophys Acta, 2002 Dec 19. PMID 12417405

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides.
    Title: Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides.
  2. Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease.
    Title: Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease.
  3. Crucial role of glucosylceramide synthase in the regulation of stem cell-like cancer cells in B16F10 murine melanoma.
    Title: Crucial role of glucosylceramide synthase in the regulation of stem cell-like cancer cells in B16F10 murine melanoma.
  4. The cell division gene PCNA was significantly overexpressed in SK2(-/-) cells, suggesting a cross regulation between sphingosine kinases and Ceramide glucosyltransferase.
    Title: The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death.
  5. we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease.
    Title: Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.
  6. These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin signaling and white adipose tissue function in fasted mice.
    Title: Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase.
  7. we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells.
    Title: Reduced UDP-glucose Levels Are Associated with P-glycoprotein Over-expression in L1210 Cells and Limit Glucosylceramide Synthase Activity.
  8. Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin signaling.
    Title: Ceramides and glucosylceramides are independent antagonists of insulin signaling.
  9. Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.
    Title: Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.
  10. The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase).
    Title: Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ceramide glucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ceramide glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cornified envelope assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucosylceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucosylceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucosylceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intestinal lipid absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leptin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein lipidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ceramide glucosyltransferase
Names
GCS
UDP-glucose:N-acylsphingosine D-glucosyltransferase
ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21
glucosylceramide synthase
glycosylceramide synthase
NP_035803.1
XP_006537848.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011673.3 → NP_035803.1  ceramide glucosyltransferase

    See identical proteins and their annotated locations for NP_035803.1

    Status: PROVISIONAL

    Source sequence(s)
    AL808112
    Consensus CDS
    CCDS18219.1
    UniProtKB/Swiss-Prot
    A2AN90, O88693
    Related
    ENSMUSP00000030074.8, ENSMUST00000030074.8
    Conserved Domains (1) summary
    cd02520
    Location:51 → 280
    Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    59189452..59222833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537785.5 → XP_006537848.1  ceramide glucosyltransferase isoform X1

    Conserved Domains (1) summary
    cd02520
    Location:51 → 284
    Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88693.1 GenPept UniProtKB/Swiss-Prot:O88693

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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