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Uck1 uridine-cytidine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 22245, updated on 2-Nov-2024

Summary

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Official Symbol
Uck1provided by MGI
Official Full Name
uridine-cytidine kinase 1provided by MGI
Primary source
MGI:MGI:98904
See related
Ensembl:ENSMUSG00000002550 AllianceGenome:MGI:98904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
URK1; Umpk
Summary
Enables uridine kinase activity. Involved in UMP salvage. Predicted to be active in cytoplasm. Is expressed in nervous system; respiratory system; and urinary system. Orthologous to human UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in mammary gland adult (RPKM 75.9), adrenal adult (RPKM 70.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uck1 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32145014..32150117, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32255002..32260105, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2B Neighboring gene predicted gene, 22192 Neighboring gene predicted gene, 25632 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10094 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9197 Neighboring gene SWI5 recombination repair homolog (yeast)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assignment of the gene for human uridine monophosphate kinase to chromosome 1 using somatic cell hybrid clone panels. Satlin A, et al. Cytogenet Cell Genet, 1975. PMID 172293
  2. The functions and consensus motifs of nine types of peptide segments that form different types of nucleotide-binding sites. Traut TW. Eur J Biochem, 1994 May 15. PMID 8200357
  3. Cloning and expression of a cDNA encoding uridine kinase from mouse brain. Ropp PA, et al. Arch Biochem Biophys, 1996 Dec 1. PMID 8951040
  4. Lifelong persistence of nuclear RNAs in the mouse brain. Zocher S, et al. Science, 2024 Apr 5. PMID 38574132, Free PMC Article
  5. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytidine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cytidine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables uridine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables uridine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in CMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in CTP salvage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in UMP salvage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in UMP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uridine-cytidine kinase 1
Names
cytidine monophosphokinase 1
uridine monophosphate kinase
uridine monophosphokinase 1
NP_001365720.1
NP_001365721.1
NP_035805.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378791.1 → NP_001365720.1  uridine-cytidine kinase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL808027
    UniProtKB/Swiss-Prot
    P52623
    Conserved Domains (1) summary
    cd02023
    Location:31 → 254
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  2. NM_001378792.1 → NP_001365721.1  uridine-cytidine kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL808027
    UniProtKB/Swiss-Prot
    P52623
    Conserved Domains (1) summary
    cd02023
    Location:12 → 187
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  3. NM_011675.2 → NP_035805.2  uridine-cytidine kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK132100, BY338721, CJ194826, L31783
    Consensus CDS
    CCDS15909.2
    UniProtKB/Swiss-Prot
    P52623
    UniProtKB/TrEMBL
    A2AN37
    Related
    ENSMUSP00000002625.9, ENSMUST00000002625.15
    Conserved Domains (2) summary
    COG0572
    Location:24 → 238
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:31 → 236
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32145014..32150117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52623.2 GenPept UniProtKB/Swiss-Prot:P52623

Gene LinkOut

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