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HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 [ Homo sapiens (human) ]

Gene ID: 222537, updated on 5-Mar-2024

Summary

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Official Symbol
HS3ST5provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 5provided by HGNC
Primary source
HGNC:HGNC:19419
See related
Ensembl:ENSG00000249853 MIM:609407; AllianceGenome:HGNC:19419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3OST5; 3-OST-5; HS3OST5; NBLA04021
Summary
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
6q21-q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (114055596..114343023, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (115238715..115526173, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (114376760..114664187, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901384 Neighboring gene HDAC2 and HS3ST5 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 9060 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:114317472-114318671 Neighboring gene NUDT19 pseudogene 3 Neighboring gene ribosomal protein SA pseudogene 43 Neighboring gene uncharacterized LOC124901383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:114524453-114524954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:114524955-114525454 Neighboring gene RNA, 5S ribosomal pseudogene 213 Neighboring gene NANOG hESC enhancer GRCh37_chr6:114603304-114603805 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:114640738-114641477 Neighboring gene uncharacterized LOC107986638 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:114683371-114683962 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:114683963-114684552 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 3090 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114742086-114742751 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114743417-114744081 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114745558-114746227 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114746228-114746898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114746899-114747567 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114747568-114748238 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114748909-114749578 Neighboring gene lncRNA periodontal mesenchymal stem cell osteogenesis related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of the structure of antithrombin-binding heparan sulfate generated by heparan sulfate 3-O-sulfotransferase 5. Chen J, et al. Biochim Biophys Acta, 2005 Sep 15. PMID 16099108
  2. The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O-sulfotransferase isoform 5. Duncan MB, et al. Biochim Biophys Acta, 2004 Mar 17. PMID 15026143
  3. Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia. Wang Q, et al. PLoS One, 2013. PMID 24086445, Free PMC Article
  4. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. Mochizuki H, et al. J Biol Chem, 2003 Jul 18. PMID 12740361
  5. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. Xia G, et al. J Biol Chem, 2002 Oct 4. PMID 12138164

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
  2. Recombinant 3-OST-5 only exhibited sulfotransferase activity toward heparan sulfate and heparin. 3-OST-5 was highly expressed in fetal brain, followed by adult brain and spinal cord, and at very low or undetectable levels in other tissues.
    Title: Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide.
  3. Results demonstrate that the human 3-O-sulfotransferase isoform 5 gene is capable of synthesizing anticoagulant heparan sulfate (HS) in CHO cells and may contribute to the biosynthesis of HS in humans.
    Title: The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O-sulfotransferase isoform 5.
  4. Structural analysis of 3-OST-5 HS(act) revealed that the antithrombin-binding site of 3-OST-5 HS(act) is located within a domain clustered with N-sulfated glucosamine units.
    Title: Characterization of the structure of antithrombin-binding heparan sulfate generated by heparan sulfate 3-O-sulfotransferase 5.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification TAS
Traceable Author Statement
more info
  
involved_in negative regulation of coagulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 5
Names
h3-OST-5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
heparan sulfate 3-O-sulfotransferase 5
heparan sulfate 3-OST-5
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
NP_001373968.1
NP_001373969.1
NP_001373970.1
NP_001373971.1
NP_001373972.1
NP_001373973.1
NP_001373974.1
NP_001373975.1
NP_001373976.1
NP_705840.2
XP_011533890.1
XP_016865960.1
XP_054210617.1
XP_054210618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387039.1 → NP_001373968.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001387040.1 → NP_001373969.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  3. NM_001387041.1 → NP_001373970.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  4. NM_001387042.1 → NP_001373971.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  5. NM_001387043.1 → NP_001373972.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  6. NM_001387044.1 → NP_001373973.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  7. NM_001387045.1 → NP_001373974.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  8. NM_001387046.1 → NP_001373975.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  9. NM_001387047.1 → NP_001373976.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  10. NM_153612.4 → NP_705840.2  heparan sulfate glucosamine 3-O-sulfotransferase 5

    See identical proteins and their annotated locations for NP_705840.2

    Status: VALIDATED

    Source sequence(s)
    AL136446, AL355498, AL500524
    Consensus CDS
    CCDS34517.1
    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Related
    ENSP00000427888.1, ENST00000312719.10
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    114055596..114343023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010471.2 → XP_016865960.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_011535588.3 → XP_011533890.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_011533890.1

    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    115238715..115526173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354642.1 → XP_054210617.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285

  2. XM_054354643.1 → XP_054210618.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K1J2, Q52LI2, Q8IZT8, Q8N285
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZT8.1 GenPept UniProtKB/Swiss-Prot:Q8IZT8

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