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Utf1 undifferentiated embryonic cell transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 22286, updated on 2-Nov-2024

Summary

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Official Symbol
Utf1provided by MGI
Official Full Name
undifferentiated embryonic cell transcription factor 1provided by MGI
Primary source
MGI:MGI:1276125
See related
Ensembl:ENSMUSG00000047751 AllianceGenome:MGI:1276125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables HMG box domain binding activity; TBP-class protein binding activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; gonad; and limb mesenchyme. Orthologous to human UTF1 (undifferentiated embryonic cell transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 7.2), thymus adult (RPKM 4.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Utf1 in Genome Data Viewer
Location:
7 F4; 7 84.91 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139523769..139525025)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139943856..139945112)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene kinase non-catalytic C-lobe domain (KIND) containing 1 Neighboring gene STARR-seq mESC enhancer starr_20433 Neighboring gene STARR-seq mESC enhancer starr_20437 Neighboring gene predicted gene 16201 Neighboring gene microRNA 7686 Neighboring gene microRNA 202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer. Raina K, et al. Stem Cell Rev Rep, 2021 Aug. PMID 33517544
  2. Carboxy-terminally truncated form of a coactivator UTF1 stimulates transcription from a variety of gene promoters through the TATA Box. Fukushima A, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329418
  3. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Nishimoto M, et al. Mol Cell Biol, 1999 Aug. PMID 10409735, Free PMC Article
  4. Utf1 contributes to intergenerational epigenetic inheritance of pluripotency. Bao Q, et al. Sci Rep, 2017 Nov 6. PMID 29097685, Free PMC Article
  5. Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1 -neo selection. Semmler J, et al. Cell Physiol Biochem, 2014. PMID 25277677

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.
    Title: An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.
  2. proper development of Utf1 null embryos almost entirely depends on the presence of functional Utf1 alleles in the parental germline. This indicates that Utf1's proposed epigenetic role in ESC pluripotency in vitro may be linked to intergenerational epigenetic inheritance in vivo.
    Title: Utf1 contributes to intergenerational epigenetic inheritance of pluripotency.
  3. UTF1 is required for embryonic development and regulates male germ cell development
    Title: Embryonic lethality and defective male germ cell development in mice lacking UTF1.
  4. LncRNA Gm2044 was identified to inhibit Utf1 mRNA translation and play important roles in spermatogenesis.
    Title: LncRNA Gm2044 highly expresses in spermatocyte and inhibits Utf1 translation by interacting with Utf1 mRNA.
  5. IPS cells derived from UTF1-selection give rise to functional CMs in vitro.
    Title: Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1 -neo selection.
  6. A large region of Utf1 was found to be necessary for direct interaction with N-Myc.
    Title: Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain.
  7. Suppression of UTF1 expression in P19 cells by RNA interference enhanced retinoic acid (RA)-induced neuronal differentiation.
    Title: UTF1 deficiency promotes retinoic acid-induced neuronal differentiation in P19 embryonal carcinoma cells.
  8. Data show that UTF1 is a key chromatin component in ES cells, preventing ES cell chromatin decondensation, and aberrant gene expression; both essential for proper initiation of lineage-specific differentiation of ES cells.
    Title: Undifferentiated embryonic cell transcription factor 1 regulates ESC chromatin organization and gene expression.
  9. UTF1 is a strongly chromatin-associated protein involved in the initiation of ES cell differentiation.
    Title: UTF1 is a chromatin-associated protein involved in ES cell differentiation.
  10. These results suggest a molecular pathway by which Oct-3/4 induces rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene.
    Title: Oct-3/4 maintains the proliferative embryonic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables HMG box domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables TBP-class protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
undifferentiated embryonic cell transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009482.2 → NP_033508.1  undifferentiated embryonic cell transcription factor 1

    See identical proteins and their annotated locations for NP_033508.1

    Status: PROVISIONAL

    Source sequence(s)
    AC107822
    Consensus CDS
    CCDS21958.1
    UniProtKB/Swiss-Prot
    O70530, Q6J1H4
    UniProtKB/TrEMBL
    B2RSF1
    Related
    ENSMUSP00000128848.3, ENSMUST00000168457.3
    Conserved Domains (1) summary
    pfam13837
    Location:79 → 126
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139523769..139525025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J1H4.2 GenPept UniProtKB/Swiss-Prot:Q6J1H4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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