Utrn utrophin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Utrnprovided by MGI
Official Full Name: utrophinprovided by MGI
Primary source: MGI:MGI:104631
See related: Ensembl:ENSMUSG00000019820 AllianceGenome:MGI:104631
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DRP; Dmdl
Summary: Predicted to enable cytoskeletal protein binding activity; integrin binding activity; and protein kinase binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion and synaptic signaling. Predicted to act upstream of or within adult somatic muscle development. Located in neuromuscular junction and sarcolemma. Part of dystrophin-associated glycoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; digit mesenchyme; genitourinary system; and nasal epithelium. Used to study Duchenne muscular dystrophy. Orthologous to human UTRN (utrophin). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in lung adult (RPKM 10.2), bladder adult (RPKM 7.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 3.77 cM

Exon count:: 81

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (12257931..12745632, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (12382187..12869888, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice.
Title: Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice.
Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury.
Title: Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury.
Social stress is lethal in the mdx model of Duchenne muscular dystrophy.
Title: Social stress is lethal in the mdx model of Duchenne muscular dystrophy.
Distinct mechanical properties in homologous spectrin-like repeats of utrophin.
Title: Distinct mechanical properties in homologous spectrin-like repeats of utrophin.
we show that even low levels of exon skipping and dystrophin restoration are sufficient to significantly increase the survival of mdx-utrn-/- mice from 70 to 97 days.
Title: Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.
UtroUp recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation.
Title: UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation.
The dystrophin-/-/utrophin-/-/ double knockout (dKO-Hom) mouse is a murine model of human Duchenne muscular dystrophy. This study investigated the bone and muscle abnormalities of dKO-Hom mouse and mechanisms.
Title: Systemic investigation of bone and muscle abnormalities in dystrophin/utrophin double knockout mice during postnatal development and the mechanisms.
these findings support a model in which utrophin-derived therapies might be used to treat clinical dystrophin deficiency, with a favorable immunologic profile and preserved function in the face of extreme miniaturization.
Title: Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models.
As the more efficient utrophin-based response in mdx skeletal muscle appears to involve independent transcriptional activation of conserved, myogenic isoforms (A' and F), elevating their paralogues in DMD patients is an encouraging therapeutic strategy.
Title: Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin-deficient mice and Duchenne muscular dystrophy.
This study demonstrates the contribution of Dp427 and utrophin in male fertility, suggesting a potential pathology in DMD patients.
Title: Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125005 (e-PCR)
- UniSTS:161827

D0M10Mit1 (e-PCR)
- UniSTS:125993

D10Mit1 (e-PCR), detects polymorphism
- UniSTS:125993

D10Mit1.1 (e-PCR), detects polymorphism
- UniSTS:125994

Utrn (e-PCR), detects polymorphism
- UniSTS:144740

AU049853 (e-PCR)
- UniSTS:146299

D10Mit246 (e-PCR), detects polymorphism
- UniSTS:126150

Y12229 (e-PCR)
- UniSTS:159951

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables vinculin binding	IEA Inferred from Electronic Annotation more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult somatic muscle development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in contractile ring	IEA Inferred from Electronic Annotation more info
colocalizes_with contractile ring	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
part_of dystrophin-associated glycoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: utrophin

Names: G-utrophin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011682.4 → NP_035812.3 utrophin

See identical proteins and their annotated locations for NP_035812.3

Status: VALIDATED

Source sequence(s)

AC153565, AC156952, AK087303, AK134424, BC062163, CF162859, CN696562, X83506

Consensus CDS

CCDS35841.1

UniProtKB/TrEMBL

E9Q6R7, O08614

Related

ENSMUSP00000076093.5, ENSMUST00000076817.5

Conserved Domains (8) summary

COG5069
Location:32 → 269

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:878 → 1493

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:310 → 526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2815 → 2843

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3066 → 3114

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1307 → 1833

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2880 → 3041

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:739 → 904

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

12257931..12745632 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512708.5 → XP_006512771.1 utrophin isoform X2

See identical proteins and their annotated locations for XP_006512771.1

UniProtKB/TrEMBL

E9Q6R7, O08614

Related

ENSMUSP00000151431.2, ENSMUST00000218635.2

Conserved Domains (8) summary

COG5069
Location:32 → 269

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:878 → 1493

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:310 → 526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2815 → 2843

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3066 → 3114

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1307 → 1833

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2880 → 3041

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:739 → 904

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_011243167.3 → XP_011241469.1 utrophin isoform X5

See identical proteins and their annotated locations for XP_011241469.1

UniProtKB/TrEMBL

O08614

Conserved Domains (8) summary

COG5069
Location:21 → 241

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:850 → 1465

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:282 → 498

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2787 → 2815

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3038 → 3086

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1279 → 1805

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2852 → 3013

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:711 → 876

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512710.5 → XP_006512773.1 utrophin isoform X2

See identical proteins and their annotated locations for XP_006512773.1

UniProtKB/TrEMBL

E9Q6R7, O08614

Conserved Domains (8) summary

COG5069
Location:32 → 269

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:878 → 1493

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:310 → 526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2815 → 2843

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3066 → 3114

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1307 → 1833

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2880 → 3041

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:739 → 904

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512707.5 → XP_006512770.1 utrophin isoform X2

See identical proteins and their annotated locations for XP_006512770.1

UniProtKB/TrEMBL

E9Q6R7, O08614

Conserved Domains (8) summary

COG5069
Location:32 → 269

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:878 → 1493

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:310 → 526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2815 → 2843

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3066 → 3114

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1307 → 1833

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2880 → 3041

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:739 → 904

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512709.5 → XP_006512772.1 utrophin isoform X2

See identical proteins and their annotated locations for XP_006512772.1

UniProtKB/TrEMBL

E9Q6R7, O08614

Conserved Domains (8) summary

COG5069
Location:32 → 269

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:878 → 1493

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:310 → 526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2815 → 2843

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3066 → 3114

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1307 → 1833

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2880 → 3041

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:739 → 904

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_030245067.2 → XP_030100927.1 utrophin isoform X5

UniProtKB/TrEMBL

O08614

Conserved Domains (8) summary

COG5069
Location:21 → 241

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:850 → 1465

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:282 → 498

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2787 → 2815

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3038 → 3086

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1279 → 1805

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2852 → 3013

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:711 → 876

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512711.5 → XP_006512774.1 utrophin isoform X3

UniProtKB/TrEMBL

O08614

Conserved Domains (8) summary

COG5069
Location:22 → 266

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:875 → 1490

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:307 → 523

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2812 → 2840

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3063 → 3111

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1304 → 1830

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2877 → 3038

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:736 → 901

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512706.5 → XP_006512769.1 utrophin isoform X1

UniProtKB/TrEMBL

O08614

Conserved Domains (8) summary

COG5069
Location:37 → 274

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:883 → 1502

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:315 → 531

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2820 → 2848

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3071 → 3119

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1312 → 1838

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2885 → 3046

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:744 → 909

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512712.5 → XP_006512775.1 utrophin isoform X4

UniProtKB/TrEMBL

O08614

Conserved Domains (8) summary

COG5069
Location:37 → 274

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:883 → 1498

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:315 → 531

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2820 → 2848

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3071 → 3119

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1312 → 1838

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2885 → 3046

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:744 → 909

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512713.4 → XP_006512776.1 utrophin isoform X5

See identical proteins and their annotated locations for XP_006512776.1

UniProtKB/TrEMBL

O08614

Conserved Domains (8) summary

COG5069
Location:21 → 241

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

PRK03918
Location:850 → 1465

PRK03918; DNA double-strand break repair ATPase Rad50

cd00176
Location:282 → 498

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2787 → 2815

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3038 → 3086

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam15921
Location:1279 → 1805

CCDC158; Coiled-coil domain-containing protein 158

cd16247
Location:2852 → 3013

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:711 → 876

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006512715.5 → XP_006512778.1 utrophin isoform X6

See identical proteins and their annotated locations for XP_006512778.1

UniProtKB/TrEMBL

Q61636

Related

ENSMUSP00000151592.2, ENSMUST00000217994.2

Conserved Domains (4) summary

cd00176
Location:44 → 245

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:372 → 400

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:623 → 671

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:437 → 598

EFh_UTRO; EF-hand-like motif found in utrophin
XM_030245068.1 → XP_030100928.1 utrophin isoform X9

Conserved Domains (4) summary

cd00176
Location:7 → 175

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:302 → 330

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:553 → 601

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:367 → 528

EFh_UTRO; EF-hand-like motif found in utrophin
XM_017313925.2 → XP_017169414.1 utrophin isoform X7

UniProtKB/TrEMBL

A0A1W2P7C0

Related

ENSMUSP00000151628.2, ENSMUST00000219003.2

Conserved Domains (4) summary

cd00176
Location:7 → 214

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:341 → 369

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:592 → 640

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:406 → 567

EFh_UTRO; EF-hand-like motif found in utrophin
XM_006512717.4 → XP_006512780.1 utrophin isoform X8

Conserved Domains (4) summary

cd00176
Location:7 → 214

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:341 → 369

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:592 → 640

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16247
Location:406 → 567

EFh_UTRO; EF-hand-like motif found in utrophin