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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_009500.2 → NP_033526.1 guanine nucleotide exchange factor VAV2
See identical proteins and their annotated locations for NP_033526.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
- Source sequence(s)
-
AI847175, AL772282, BC053060, U37017
- Consensus CDS
-
CCDS15827.1
- UniProtKB/Swiss-Prot
- A2AH49, Q60992
- UniProtKB/TrEMBL
-
Q7TSI6
- Related
- ENSMUSP00000062782.8, ENSMUST00000056176.8
- Conserved Domains (8) summary
-
- cd10406
Location:657 → 759
- SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
- cd11977
Location:809 → 866
- SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
- cd11980
Location:580 → 639
- SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
- cd00029
Location:514 → 561
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- cd01223
Location:384 → 506
- PH_Vav; Vav pleckstrin homology (PH) domain
- pfam00169
Location:401 → 502
- PH; PH domain
- pfam00621
Location:197 → 370
- RhoGEF; RhoGEF domain
- pfam11971
Location:18 → 103
- CAMSAP_CH; CAMSAP CH domain
RNA
-
NR_133905.1 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks a 5' exon and contains several additional exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AI847175, AL772282, BC053060
- Related
-
ENSMUST00000185188.8
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000068.8 Reference GRCm39 C57BL/6J
- Range
-
27152116..27317620 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006497858.3 → XP_006497921.1 guanine nucleotide exchange factor VAV2 isoform X4
See identical proteins and their annotated locations for XP_006497921.1
- UniProtKB/TrEMBL
-
Q7TSI6
- Conserved Domains (7) summary
-
- cd10406
Location:657 → 759
- SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
- cd11977
Location:780 → 837
- SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
- cd11980
Location:580 → 639
- SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
- smart00325
Location:197 → 370
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
- cd00029
Location:514 → 561
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- cd01223
Location:384 → 506
- PH_Vav; Vav pleckstrin homology (PH) domain
- pfam11971
Location:18 → 103
- CAMSAP_CH; CAMSAP CH domain
-
XM_006497856.2 → XP_006497919.1 guanine nucleotide exchange factor VAV2 isoform X2
- UniProtKB/TrEMBL
-
Q7TSI6
- Conserved Domains (7) summary
-
- cd10406
Location:662 → 764
- SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
- cd11977
Location:814 → 871
- SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
- cd11980
Location:585 → 644
- SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
- smart00325
Location:197 → 370
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
- cd00029
Location:519 → 566
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- cd01223
Location:384 → 511
- PH_Vav; Vav pleckstrin homology (PH) domain
- pfam11971
Location:18 → 103
- CAMSAP_CH; CAMSAP CH domain
-
XM_006497854.2 → XP_006497917.1 guanine nucleotide exchange factor VAV2 isoform X1
- UniProtKB/TrEMBL
-
Q7TSI6
- Conserved Domains (7) summary
-
- cd10406
Location:667 → 769
- SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
- cd11977
Location:819 → 876
- SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
- cd11980
Location:590 → 649
- SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
- smart00325
Location:202 → 375
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
- cd00029
Location:524 → 571
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- cd01223
Location:389 → 516
- PH_Vav; Vav pleckstrin homology (PH) domain
- pfam11971
Location:18 → 103
- CAMSAP_CH; CAMSAP CH domain
-
XM_030249470.2 → XP_030105330.1 guanine nucleotide exchange factor VAV2 isoform X3
- Conserved Domains (7) summary
-
- cd10406
Location:662 → 764
- SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
- cd11977
Location:814 → 871
- SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
- cd11980
Location:585 → 644
- SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
- smart00325
Location:202 → 375
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
- cd00029
Location:519 → 566
- C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
- cd01223
Location:389 → 511
- PH_Vav; Vav pleckstrin homology (PH) domain
- cl00030
Location:71 → 108
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...