Vdac3 voltage-dependent anion channel 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vdac3provided by MGI
Official Full Name: voltage-dependent anion channel 3provided by MGI
Primary source: MGI:MGI:106922
See related: Ensembl:ENSMUSG00000008892 AllianceGenome:MGI:106922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable voltage-gated monoatomic anion channel activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within behavioral fear response; learning; and neuron-neuron synaptic transmission. Located in mitochondrion. Orthologous to human VDAC3 (voltage dependent anion channel 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 68.2), testis adult (RPKM 53.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.42 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (23067091..23083829, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22577075..22593813, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that knocking out mitochondrial VDAC3 increases ROS, alters renal sodium transport, and leads to hypertension.
Title: Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport.
Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2.
Title: An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.
Abnormal regulation of VDACs negatively affected sperm function. Thus, VDACs may be key regulators of the fertilization ability of spermatozoa.
Title: Voltage-dependent anion channels are a key factor of male fertility.
(n VDAC3 deficient mice the defect is restricted to the heart and only to complex IV.
Title: VDAC3 has differing mitochondrial functions in two types of striated muscles.
Bid catalyzes MAC formation in isolated mitochondria containing Bax and/or Bak with a time course of minutes and does not require VDAC1 or VDAC3.
Title: Assembly of the mitochondrial apoptosis-induced channel, MAC.
Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.
Title: Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

VDAC3 (e-PCR)
- UniSTS:506223

NoName (e-PCR)
- UniSTS:225251

RH127358 (e-PCR)
- UniSTS:210668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables porin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm mitochondrial sheath assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of pore complex	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent anion-selective channel protein 3

Names: VDAC-3; channel protein VDAC3; mVDAC3; mitochondrial outer membrane protein; outer mitochondrial membrane protein porin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198998.1 → NP_001185927.1 voltage-dependent anion-selective channel protein 3 isoform 1

See identical proteins and their annotated locations for NP_001185927.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK002296, AK146957, BY103517

UniProtKB/TrEMBL

Q3TTN3, Q5EBQ0

Conserved Domains (1) summary

cd07306
Location:5 → 283

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
NM_011696.2 → NP_035826.1 voltage-dependent anion-selective channel protein 3 isoform 2

See identical proteins and their annotated locations for NP_035826.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' coding region, compared to variant 1, and encodes an isoform (2) that is one amino acid shorter than isoform 1.

Source sequence(s)

AK002296, AK150741, BY103517

Consensus CDS

CCDS22179.1

UniProtKB/Swiss-Prot

Q60931, Q8BNG2

UniProtKB/TrEMBL

Q3TTN3, Q3TX38

Related

ENSMUSP00000009036.4, ENSMUST00000009036.11

Conserved Domains (1) summary

cd07306
Location:5 → 282

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane