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Cyp2d34 cytochrome P450, family 2, subfamily d, polypeptide 34 [ Mus musculus (house mouse) ]

Gene ID: 223706, updated on 28-Oct-2024

Summary

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Official Symbol
Cyp2d34provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily d, polypeptide 34provided by MGI
Primary source
MGI:MGI:2385022
See related
Ensembl:ENSMUSG00000094559 AllianceGenome:MGI:2385022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward colon adult (RPKM 133.9) See more
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Genomic context

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See Cyp2d34 in Genome Data Viewer
Location:
15 E1; 15 38.66 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82500164..82505157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82615963..82620956, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39298 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 33, pseudogene Neighboring gene STARR-seq mESC enhancer starr_39299 Neighboring gene STARR-seq mESC enhancer starr_39300 Neighboring gene STARR-seq mESC enhancer starr_39301 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 34, pseudogene Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 13 Neighboring gene cytochrome P450, family 2, subfamily d, member 35, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC18824

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anandamide 11,12 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 14,15 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 8,9 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450, family 2, subfamily d, polypeptide 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145474.2 → NP_663449.2  cytochrome P450, family 2, subfamily d, polypeptide 34

    Status: PROVISIONAL

    Source sequence(s)
    AC118710
    Consensus CDS
    CCDS37161.1
    UniProtKB/TrEMBL
    L7N463
    Related
    ENSMUSP00000105141.2, ENSMUST00000109515.3
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82500164..82505157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316570.1 → XP_017172059.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 421
    p450; Cytochrome P450

  2. XM_030248505.1 → XP_030104365.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X4

    Conserved Domains (1) summary
    pfam00067
    Location:37 → 511
    p450; Cytochrome P450

  3. XM_030248504.1 → XP_030104364.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:37 → 398
    p450; Cytochrome P450

  4. XM_017316571.2 → XP_017172060.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:37 → 332
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version

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