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Mpped1 metallophosphoesterase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 223726, updated on 2-Nov-2024

Summary

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Official Symbol
Mpped1provided by MGI
Official Full Name
metallophosphoesterase domain containing 1provided by MGI
Primary source
MGI:MGI:106316
See related
Ensembl:ENSMUSG00000041708 AllianceGenome:MGI:106316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6230403M19; D15Bwg0669e
Summary
Predicted to enable hydrolase activity. Is expressed in brain and tooth. Orthologous to human MPPED1 (metallophosphoesterase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 22.0), cortex adult (RPKM 14.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Mpped1 in Genome Data Viewer
Location:
15 E1; 15 39.44 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83656256..83742688)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83779472..83858487)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene signal peptide, CUB domain, EGF-like 1 Neighboring gene predicted gene, 52183 Neighboring gene predicted gene, 33324 Neighboring gene STARR-seq mESC enhancer starr_39343 Neighboring gene predicted gene, 52172 Neighboring gene predicted gene, 41370 Neighboring gene STARR-seq mESC enhancer starr_39344 Neighboring gene predicted gene, 41372 Neighboring gene EF-hand calcium binding domain 6 Neighboring gene ribosomal protein L31, pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon. Chen CM, et al. Dev Dyn, 2010 Jun. PMID 20503375
  2. NOVA2 regulates neural circRNA biogenesis. Knupp D, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34157123, Free PMC Article
  3. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Telley L, et al. Science, 2019 May 10. PMID 31073041
  4. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Boyle MP, et al. J Comp Neurol, 2011 Aug 1. PMID 21491433
  5. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
metallophosphoesterase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359131.1 → NP_001346060.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL513354, AL591964
    Consensus CDS
    CCDS37164.1
    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
    Related
    ENSMUSP00000105096.2, ENSMUST00000109470.8
    Conserved Domains (1) summary
    cd07379
    Location:91 → 303
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  2. NM_001359132.1 → NP_001346061.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL513354, AL591964
    Consensus CDS
    CCDS37164.1
    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
    Conserved Domains (1) summary
    cd07379
    Location:91 → 303
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  3. NM_001416023.1 → NP_001402952.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL591964
    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

  4. NM_001416024.1 → NP_001402953.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL591964
    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

  5. NM_001416025.1 → NP_001402954.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL591964
    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

  6. NM_001416026.1 → NP_001402955.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL591964
    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2

  7. NM_001416027.1 → NP_001402956.1  metallophosphoesterase domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL591964
    UniProtKB/TrEMBL
    E9Q0C0

  8. NM_001416028.1 → NP_001402957.1  metallophosphoesterase domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL591964
    UniProtKB/TrEMBL
    E9Q0C0
    Related
    ENSMUSP00000126242.2, ENSMUST00000163723.8

  9. NM_172610.4 → NP_766198.1  metallophosphoesterase domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL513354, AL591964
    Consensus CDS
    CCDS37164.1
    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
    Related
    ENSMUSP00000041981.6, ENSMUST00000046168.12
    Conserved Domains (1) summary
    cd07379
    Location:91 → 303
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

RNA

  1. NR_152841.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL513354, AL591964

  2. NR_183244.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL513354, AL591964
    Related
    ENSMUST00000123387.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83656256..83742688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520817.5 → XP_006520880.1  metallophosphoesterase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006520880.1

    UniProtKB/Swiss-Prot
    A6PW09, Q3TMS4, Q3TYC7, Q91ZG2
    Conserved Domains (1) summary
    cd07379
    Location:91 → 303
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZG2.1 GenPept UniProtKB/Swiss-Prot:Q91ZG2

Gene LinkOut

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