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Fmnl3 formin-like 3 [ Mus musculus (house mouse) ]

Gene ID: 22379, updated on 28-Oct-2024

Summary

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Official Symbol
Fmnl3provided by MGI
Official Full Name
formin-like 3provided by MGI
Primary source
MGI:MGI:109569
See related
Ensembl:ENSMUSG00000023008 AllianceGenome:MGI:109569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wbp3; FBP11; mKIAA2014; 2700073B04Rik
Summary
Enables GTPase activating protein binding activity. Predicted to be involved in several processes, including cortical actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and retina. Orthologous to human FMNL3 (formin like 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lung adult (RPKM 22.2), ovary adult (RPKM 18.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fmnl3 in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99215091..99268375, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99317210..99370521, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene STARR-positive B cell enhancer ABC_E7417 Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99163430-99163646 Neighboring gene STARR-seq mESC enhancer starr_39705 Neighboring gene STARR-positive B cell enhancer ABC_E9923 Neighboring gene STARR-positive B cell enhancer ABC_E3156 Neighboring gene predicted gene, 22951 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E761 Neighboring gene VISTA enhancer mm1635 Neighboring gene NCK-associated protein 5-like Neighboring gene NCK-associated protein 5-like, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends. Heimsath EG Jr, et al. J Biol Chem, 2012 Jan 27. PMID 22094460, Free PMC Article
  2. FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation. Thompson ME, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23222643, Free PMC Article
  3. FMNL formins boost lamellipodial force generation. Kage F, et al. Nat Commun, 2017 Mar 22. PMID 28327544, Free PMC Article
  4. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. Gauvin TJ, et al. Mol Biol Cell, 2015 Feb 1. PMID 25428984, Free PMC Article
  5. FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42. Kage F, et al. Sci Rep, 2017 Aug 29. PMID 28852060, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus.
    Title: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.
  2. force generation in lamellipodia strongly depends on FMNL formin activity.
    Title: FMNL formins boost lamellipodial force generation.
  3. FMNL3 functions in assembly of actin-based protrusions that are specialized for cell-cell adhesion.
    Title: The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.
  4. 3.4-A structure of FMNL3 FH2 dimer in complex with tetramethylrhodamine-actin uncovers details of formin-regulated actin elongation; structure provides details for FH2-mediated filament elongation by processive capping and supports a model in which C-terminal non-FH2 residues of FMNL3 are required to stabilize the filament nucleus
    Title: FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation.
  5. The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends.
    Title: The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activating protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
formin-like protein 3
Names
WW domain binding protein 3
formin-like 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310622.1 → NP_001297551.1  formin-like protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC118646, AK163361, AU042388, BC131961
    Consensus CDS
    CCDS79409.1
    UniProtKB/TrEMBL
    D3Z7A7
    Related
    ENSMUSP00000113094.2, ENSMUST00000120633.2
    Conserved Domains (3) summary
    pfam02181
    Location:561 → 926
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:281 → 472
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:26 → 278
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. NM_001310623.1 → NP_001297552.1  formin-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001297552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon in the mid region and the penultimate exon compared to variant 1. The resulting isoform (3) is shorter missing an internal protein segment and with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC118646, AU042388, BC131961
    Consensus CDS
    CCDS79408.1
    UniProtKB/Swiss-Prot
    Q6ZPF4
    Related
    ENSMUSP00000079984.8, ENSMUST00000081224.14
    Conserved Domains (3) summary
    pfam02181
    Location:510 → 875
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:230 → 421
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:26 → 227
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. NM_011711.2 → NP_035841.1  formin-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_035841.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC118646, AU042388, BC131961
    Consensus CDS
    CCDS27819.1
    UniProtKB/Swiss-Prot
    Q3TCF9, Q3U2E4, Q6ZPF4
    Related
    ENSMUSP00000085566.7, ENSMUST00000088233.13
    Conserved Domains (3) summary
    pfam02181
    Location:561 → 926
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:281 → 472
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:26 → 278
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99215091..99268375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520844.5 → XP_006520907.1  formin-like protein 3 isoform X1

    Conserved Domains (3) summary
    pfam02181
    Location:510 → 875
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:230 → 421
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:26 → 227
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. XM_030248512.2 → XP_030104372.1  formin-like protein 3 isoform X2

    Conserved Domains (3) summary
    pfam02181
    Location:327 → 692
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:47 → 238
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:1 → 44
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZPF4.2 GenPept UniProtKB/Swiss-Prot:Q6ZPF4

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