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Zfp758 zinc finger protein 758 [ Mus musculus (house mouse) ]

Gene ID: 224598, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp758provided by MGI
Official Full Name
zinc finger protein 758provided by MGI
Primary source
MGI:MGI:2385044
See related
Ensembl:ENSMUSG00000044501 AllianceGenome:MGI:2385044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human ZNF300 (zinc finger protein 300). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 1.5), placenta adult (RPKM 0.9) and 25 other tissues See more
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Genomic context

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See Zfp758 in Genome Data Viewer
Location:
17 A3.3; 17 11.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (22580406..22612890)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (22361430..22393909)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52309 Neighboring gene zinc finger protein 994 Neighboring gene STARR-seq mESC enhancer starr_42025 Neighboring gene STARR-positive B cell enhancer ABC_E4195 Neighboring gene STARR-seq mESC enhancer starr_42027 Neighboring gene predicted gene 7072 Neighboring gene STARR-seq mESC enhancer starr_42028 Neighboring gene predicted gene, 53992 Neighboring gene STARR-positive B cell enhancer ABC_E5576 Neighboring gene STARR-seq mESC enhancer starr_42030 Neighboring gene zinc finger protein 944 Neighboring gene STARR-seq mESC enhancer starr_42031 Neighboring gene STARR-positive B cell enhancer ABC_E5577 Neighboring gene STARR-seq mESC enhancer starr_42032 Neighboring gene zinc finger protein 946 Neighboring gene STARR-seq mESC enhancer starr_42034 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC29357, MGC67807

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 758

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347330.1 → NP_001334259.1  zinc finger protein 758 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117244, BX515134
    Consensus CDS
    CCDS84277.1
    UniProtKB/TrEMBL
    E9QAA1
    Related
    ENSMUSP00000121288.2, ENSMUST00000149699.8

  2. NM_001357990.2 → NP_001344919.1  zinc finger protein 758 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117244
    Consensus CDS
    CCDS37470.1
    UniProtKB/TrEMBL
    E9Q462
    Related
    ENSMUSP00000113532.2, ENSMUST00000121315.2
    Conserved Domains (3) summary
    COG5048
    Location:203 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

  3. NM_001410502.1 → NP_001397431.1  zinc finger protein 758 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117244
    UniProtKB/TrEMBL
    E9Q462

  4. NM_001410503.1 → NP_001397432.1  zinc finger protein 758 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117244

  5. NM_001410504.1 → NP_001397433.1  zinc finger protein 758 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117244

  6. NM_145484.2 → NP_663459.2  zinc finger protein 758 isoform 1

    See identical proteins and their annotated locations for NP_663459.2

    Status: VALIDATED

    Source sequence(s)
    AC117244, BC022203, BX515134
    Consensus CDS
    CCDS37470.1
    UniProtKB/TrEMBL
    E9Q462
    Related
    ENSMUSP00000086143.3, ENSMUST00000088765.9
    Conserved Domains (3) summary
    COG5048
    Location:203 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

RNA

  1. NR_177080.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117244

  2. NR_177081.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117244

  3. NR_177082.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117244

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    22580406..22612890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003952106.2 RNA Sequence

  2. XR_004939511.1 RNA Sequence

  3. XR_004939512.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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