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Fez2 fasciculation and elongation protein zeta 2 [ Mus musculus (house mouse) ]

Gene ID: 225020, updated on 2-Nov-2024

Summary

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Official Symbol
Fez2provided by MGI
Official Full Name
fasciculation and elongation protein zeta 2provided by MGI
Primary source
MGI:MGI:2675856
See related
Ensembl:ENSMUSG00000056121 AllianceGenome:MGI:2675856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030616F16; D17Ertd315e
Summary
Predicted to be involved in negative regulation of autophagosome assembly. Predicted to be active in axon and cytoplasm. Is expressed in embryo. Orthologous to human FEZ2 (fasciculation and elongation protein zeta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 18.4), cerebellum adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fez2 in Genome Data Viewer
Location:
17 E2- E3; 17 48.57 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (78676641..78725581, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78369212..78418152, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cysteine rich transmembrane BMP regulator 1 Neighboring gene predicted gene, 41620 Neighboring gene predicted gene, 52306 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:78761825-78761978 Neighboring gene STARR-seq mESC enhancer starr_43268 Neighboring gene predicted gene, 32336 Neighboring gene predicted gene, 53960 Neighboring gene predicted gene, 32464 Neighboring gene 60S ribosomal protein L39 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Fujita T, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697253
  2. Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth. Lee S, et al. Hum Mol Genet, 2005 Mar 1. PMID 15649943
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner
    Title: Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fasciculation and elongation protein zeta-2
Names
zygin 2
zygin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285940.1 → NP_001272869.1  fasciculation and elongation protein zeta-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC103598, AC151270
    Consensus CDS
    CCDS70844.1
    UniProtKB/TrEMBL
    D3Z6D5, Q6P395
    Related
    ENSMUSP00000108106.2, ENSMUST00000112487.3
    Conserved Domains (1) summary
    pfam07763
    Location:42 → 265
    FEZ; FEZ-like protein

  2. NM_001285946.1 → NP_001272875.1  fasciculation and elongation protein zeta-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC103598, AC151270
    Consensus CDS
    CCDS89154.1
    UniProtKB/TrEMBL
    A0A3Q4EGS7, Q6P395
    Related
    ENSMUSP00000157359.2, ENSMUST00000234029.2
    Conserved Domains (1) summary
    pfam07763
    Location:42 → 265
    FEZ; FEZ-like protein

  3. NM_001285949.1 → NP_001272878.1  fasciculation and elongation protein zeta-2 isoform 4

    See identical proteins and their annotated locations for NP_001272878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences including the use of an alternate 3' terminal exon. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC103598, AC151270
    Consensus CDS
    CCDS89155.1
    UniProtKB/TrEMBL
    Q3TN06, Q6P395
    Related
    ENSMUSP00000157187.2, ENSMUST00000234052.2
    Conserved Domains (1) summary
    pfam07763
    Location:42 → 265
    FEZ; FEZ-like protein

  4. NM_001360407.1 → NP_001347336.1  fasciculation and elongation protein zeta-2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC103598, AC151270
    Consensus CDS
    CCDS89156.1
    UniProtKB/TrEMBL
    A0A3Q4EH67, Q6P395
    Related
    ENSMUSP00000157338.2, ENSMUST00000234530.2
    Conserved Domains (1) summary
    pfam07763
    Location:42 → 265
    FEZ; FEZ-like protein

  5. NM_199448.3 → NP_955519.1  fasciculation and elongation protein zeta-2 isoform 2

    See identical proteins and their annotated locations for NP_955519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to vatiant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC103598, AC151270, AK150241
    Consensus CDS
    CCDS28977.1
    UniProtKB/Swiss-Prot
    Q6TYB5
    UniProtKB/TrEMBL
    Q3U049, Q6P395
    Related
    ENSMUSP00000068987.8, ENSMUST00000070039.14
    Conserved Domains (1) summary
    pfam07763
    Location:42 → 265
    FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    78676641..78725581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TYB5.1 GenPept UniProtKB/Swiss-Prot:Q6TYB5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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