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Apbb3 amyloid beta precursor protein binding family B member 3 [ Mus musculus (house mouse) ]

Gene ID: 225372, updated on 2-Nov-2024

Summary

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Official Symbol
Apbb3provided by MGI
Official Full Name
amyloid beta precursor protein binding family B member 3provided by MGI
Primary source
MGI:MGI:108404
See related
Ensembl:ENSMUSG00000117679 AllianceGenome:MGI:108404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR2S; Rirl2; Fe65l2
Summary
Predicted to enable amyloid-beta binding activity; low-density lipoprotein particle receptor binding activity; and molecular adaptor activity. Predicted to be involved in negative regulation of cell cycle phase transition; negative regulation of transcription by RNA polymerase II; and positive regulation of protein secretion. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including actin cytoskeleton; cytosol; and nuclear body. Predicted to be active in cytoplasm and nucleus. Orthologous to human APBB3 (amyloid beta precursor protein binding family B member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 17.9), cerebellum adult (RPKM 16.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Apbb3 in Genome Data Viewer
Location:
18 B2; 18 19.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36804207..36812419, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36671154..36679366, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E5653 Neighboring gene steroid receptor RNA activator 1 Neighboring gene STARR-positive B cell enhancer ABC_E8708 Neighboring gene solute carrier family 35, member A4 Neighboring gene Riken cDNA E230025N22 gene Neighboring gene STARR-seq mESC enhancer starr_44297 Neighboring gene predicted gene, 41699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Pappolla MA, et al. Am J Pathol, 1998 Apr. PMID 9546346, Free PMC Article
  2. Regulation of tumor necrosis factor-and Fas-mediated apoptotic cell death by a novel cDNA TR2L. Cao H, et al. Biochem Biophys Res Commun, 1996 Oct 3. PMID 8858135
  3. Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. Guénette S, et al. EMBO J, 2006 Jan 25. PMID 16407979, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC38710

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
  
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
  
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amyloid-beta A4 precursor protein-binding family B member 3
Names
amyloid beta (A4) precursor protein-binding, family B, member 3
protein Fe65-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357512.1 → NP_001344441.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115631, AI844683
    Conserved Domains (3) summary
    smart00456
    Location:30 → 61
    WW; Domain with 2 conserved Trp (W) residues
    cd01271
    Location:284 → 414
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:116 → 255
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

  2. NM_146085.2 → NP_666197.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform 1

    See identical proteins and their annotated locations for NP_666197.1

    Status: VALIDATED

    Source sequence(s)
    AI844683, BC024809
    Consensus CDS
    CCDS29157.1
    UniProtKB/Swiss-Prot
    Q8R1C9
    UniProtKB/TrEMBL
    Q3UR23
    Related
    ENSMUSP00000001415.8, ENSMUST00000001415.9
    Conserved Domains (3) summary
    smart00456
    Location:30 → 61
    WW; Domain with 2 conserved Trp (W) residues
    cd01271
    Location:283 → 413
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:116 → 254
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36804207..36812419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161110.1 → XP_036017003.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform X1

    Conserved Domains (2) summary
    cd01271
    Location:189 → 319
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:22 → 160
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1C9.1 GenPept UniProtKB/Swiss-Prot:Q8R1C9

Gene LinkOut

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