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St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 225742, updated on 2-Nov-2024

Summary

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Official Symbol
St8sia5provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5provided by MGI
Primary source
MGI:MGI:109243
See related
Ensembl:ENSMUSG00000025425 AllianceGenome:MGI:109243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat8e; ST8SiaV
Summary
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in several processes, including N-glycan processing; glycosphingolipid biosynthetic process; and protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in brain. Orthologous to human ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 39.0), cortex adult (RPKM 14.8) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See St8sia5 in Genome Data Viewer
Location:
18 E3; 18 52.13 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77273529..77343146)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77185847..77255450)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930520E11 gene Neighboring gene protein inhibitor of activated STAT 2 Neighboring gene STARR-seq mESC enhancer starr_45110 Neighboring gene STARR-seq mESC enhancer starr_45112 Neighboring gene STARR-seq mESC enhancer starr_45115 Neighboring gene predicted gene 7276 Neighboring gene STARR-seq mESC enhancer starr_45117 Neighboring gene lipoxygenase homology domains 1 Neighboring gene USP6 N-terminal like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells. Kwak DH, et al. BMB Rep, 2011 Dec. PMID 22189683
  2. Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3. Kono M, et al. J Biol Chem, 1996 Nov 15. PMID 8910600
  3. Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR. Takashima S, et al. Biochem Biophys Res Commun, 1999 Jun 24. PMID 10381338
  4. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. Ngamukote S, et al. J Neurochem, 2007 Dec. PMID 17883393
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC41119

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosphingolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
alpha-2,8-sialyltransferase 8E
Names
SIAT8-E
sialyltransferase 8 (alpha-2, 8-sialyltransferase) E
sialyltransferase 8E
sialyltransferase St8Sia V
sialytransferase St8Sia V
NP_038694.2
NP_694764.2
XP_006526492.1
XP_006526493.1
XP_006526494.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013666.3 → NP_038694.2  alpha-2,8-sialyltransferase 8E isoform long

    See identical proteins and their annotated locations for NP_038694.2

    Status: VALIDATED

    Source sequence(s)
    AC157991
    Consensus CDS
    CCDS50325.1
    UniProtKB/Swiss-Prot
    E9QKY5, P70126, P70127, P70128
    UniProtKB/TrEMBL
    Q8JZQ3
    Related
    ENSMUSP00000074764.7, ENSMUST00000075290.8
    Conserved Domains (1) summary
    pfam00777
    Location:153 → 406
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_153124.3 → NP_694764.2  alpha-2,8-sialyltransferase 8E isoform middle

    See identical proteins and their annotated locations for NP_694764.2

    Status: VALIDATED

    Source sequence(s)
    AC157991
    Consensus CDS
    CCDS29353.1
    UniProtKB/TrEMBL
    Q3TRR3, Q8JZQ3
    Related
    ENSMUSP00000078566.5, ENSMUST00000079618.11
    Conserved Domains (1) summary
    pfam00777
    Location:117 → 370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77273529..77343146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526429.5 → XP_006526492.1  alpha-2,8-sialyltransferase 8E isoform X1

    UniProtKB/TrEMBL
    Q8JZQ3
    Conserved Domains (1) summary
    pfam00777
    Location:154 → 407
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006526430.4 → XP_006526493.1  alpha-2,8-sialyltransferase 8E isoform X2

    UniProtKB/TrEMBL
    Q8JZQ3
    Conserved Domains (1) summary
    pfam00777
    Location:118 → 371
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_006526431.4 → XP_006526494.1  alpha-2,8-sialyltransferase 8E isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:10 → 222
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177416.1: Suppressed sequence

    Description
    NM_177416.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70126.2 GenPept UniProtKB/Swiss-Prot:P70126

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