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Npas4 neuronal PAS domain protein 4 [ Mus musculus (house mouse) ]

Gene ID: 225872, updated on 2-Nov-2024

Summary

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Official Symbol
Npas4provided by MGI
Official Full Name
neuronal PAS domain protein 4provided by MGI
Primary source
MGI:MGI:2664186
See related
Ensembl:ENSMUSG00000045903 AllianceGenome:MGI:2664186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nxf; LE-PAS
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including chemical postsynaptic transmission; learning or memory; and modulation of chemical synaptic transmission. Acts upstream of or within cellular response to corticosterone stimulus and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; future forebrain; and urinary system. Orthologous to human NPAS4 (neuronal PAS domain protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 3.6), cortex adult (RPKM 2.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Npas4 in Genome Data Viewer
Location:
19 A; 19 4.2 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5034381..5053467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4984353..5003439, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pellino 3 Neighboring gene STARR-seq mESC enhancer starr_45369 Neighboring gene STARR-seq mESC enhancer starr_45370 Neighboring gene mitochondrial ribosomal protein L11 Neighboring gene solute carrier family 29 (nucleoside transporters), member 2 Neighboring gene nuclear encoded tRNA serine 6 (anticodon GCT) Neighboring gene predicted gene, 30581

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene. Furukawa-Hibi Y, et al. Neuroreport, 2015 Sep 30. PMID 26222956
  2. Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors. Funahashi Y, et al. Cell Rep, 2019 Dec 3. PMID 31801086
  3. Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2. Parekh PK, et al. J Neurosci, 2019 Jun 12. PMID 30962277, Free PMC Article
  4. Environmental enrichment improves pain sensitivity, depression-like phenotype, and memory deficit in mice with neuropathic pain: role of NPAS4. Wang XM, et al. Psychopharmacology (Berl), 2019 Jul. PMID 30798405
  5. NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus. Hartzell AL, et al. Elife, 2018 Jul 27. PMID 30052197, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain regions differences in amyloid-beta and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease.
    Title: Brain regions differences in amyloid-β and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease.
  2. NPAS4 Exacerbates Pyroptosis via Transcriptionally Regulating NLRP6 in the Acute Phase of Intracerebral Hemorrhage in Mice.
    Title: NPAS4 Exacerbates Pyroptosis via Transcriptionally Regulating NLRP6 in the Acute Phase of Intracerebral Hemorrhage in Mice.
  3. NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses.
    Title: NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses.
  4. Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning.
    Title: Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning.
  5. Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion.
    Title: Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion.
  6. Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
    Title: Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
  7. Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice.
    Title: Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice.
  8. Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
    Title: Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
  9. NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells.
    Title: NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells.
  10. NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior.
    Title: NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to acid chemical IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to corticosterone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inhibitory synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronal PAS domain-containing protein 4
Names
HLH-PAS transcription factor NXF
bHLH-PAS type transcription factor NXF
limbic-enhanced PAS protein
neuronal PAS4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153553.5 → NP_705781.1  neuronal PAS domain-containing protein 4

    See identical proteins and their annotated locations for NP_705781.1

    Status: VALIDATED

    Source sequence(s)
    AC124502
    Consensus CDS
    CCDS29445.1
    UniProtKB/Swiss-Prot
    Q3V3U3, Q8BGD7
    UniProtKB/TrEMBL
    A1L327
    Related
    ENSMUSP00000062992.8, ENSMUST00000056129.9
    Conserved Domains (3) summary
    smart00091
    Location:72 → 135
    PAS; PAS domain
    pfam08447
    Location:230 → 298
    PAS_3; PAS fold
    cd19697
    Location:2 → 57
    bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5034381..5053467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161526.1 → XP_036017419.1  neuronal PAS domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q3V3U3, Q8BGD7
    UniProtKB/TrEMBL
    A1L327
    Conserved Domains (3) summary
    smart00091
    Location:72 → 135
    PAS; PAS domain
    pfam08447
    Location:230 → 298
    PAS_3; PAS fold
    cd19697
    Location:2 → 57
    bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins

  2. XM_011248619.3 → XP_011246921.1  neuronal PAS domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011246921.1

    UniProtKB/Swiss-Prot
    Q3V3U3, Q8BGD7
    UniProtKB/TrEMBL
    A1L327
    Conserved Domains (3) summary
    smart00091
    Location:72 → 135
    PAS; PAS domain
    pfam08447
    Location:230 → 298
    PAS_3; PAS fold
    cd19697
    Location:2 → 57
    bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins

  3. XM_030250872.2 → XP_030106732.1  neuronal PAS domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q3V3U3, Q8BGD7
    UniProtKB/TrEMBL
    A1L327
    Conserved Domains (3) summary
    smart00091
    Location:72 → 135
    PAS; PAS domain
    pfam08447
    Location:230 → 298
    PAS_3; PAS fold
    cd19697
    Location:2 → 57
    bHLH-PAS_NPAS4_PASD10; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGD7.1 GenPept UniProtKB/Swiss-Prot:Q8BGD7

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