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Gstp3 glutathione S-transferase pi 3 [ Mus musculus (house mouse) ]

Gene ID: 225884, updated on 2-Nov-2024

Summary

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Official Symbol
Gstp3provided by MGI
Official Full Name
glutathione S-transferase pi 3provided by MGI
Primary source
MGI:MGI:2385078
See related
Ensembl:ENSMUSG00000058216 AllianceGenome:MGI:2385078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of macromolecule metabolic process; and negative regulation of signal transduction. Predicted to be located in mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Is expressed in liver lobe. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E18 (RPKM 88.7), liver E14.5 (RPKM 32.9) and 5 other tissues See more
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Genomic context

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See Gstp3 in Genome Data Viewer
Location:
19 A; 19 3.77 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4107470..4109587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4057470..4059605, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, pi 1 Neighboring gene glutathione S-transferase, pi 2 Neighboring gene STARR-seq mESC enhancer starr_45337 Neighboring gene STARR-positive B cell enhancer ABC_E5673 Neighboring gene predicted gene, 42060 Neighboring gene small nucleolar RNA, C/D box 3B, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex. Liu X, et al. Hum Mol Genet, 2021 Mar 25. PMID 33437989, Free PMC Article
  2. Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia. Cerrato V, et al. Glia, 2018 Sep. PMID 29732603
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
    Title: Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC37914

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-nitrosoglutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables dinitrosyl-iron complex binding ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glutathione derivative biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TRAF2-GSTP1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase P-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362043.2 → NP_001348972.1  glutathione S-transferase P-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109138
    UniProtKB/TrEMBL
    F6RWR5
    Conserved Domains (2) summary
    cl00388
    Location:1 → 59
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:67 → 186
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. NM_001426156.1 → NP_001413085.1  glutathione S-transferase P-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109138

  3. NM_144869.4 → NP_659118.1  glutathione S-transferase P-like isoform 1

    See identical proteins and their annotated locations for NP_659118.1

    Status: VALIDATED

    Source sequence(s)
    AC109138
    Consensus CDS
    CCDS79668.1
    UniProtKB/TrEMBL
    F6RWR5, Q8VC73
    Related
    ENSMUSP00000140159.2, ENSMUST00000189808.7
    Conserved Domains (3) summary
    PTZ00057
    Location:6 → 194
    PTZ00057; glutathione s-transferase; Provisional
    cd03076
    Location:3 → 76
    GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:84 → 203
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4107470..4109587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531725.4 → XP_006531788.1  glutathione S-transferase P-like isoform X3

    See identical proteins and their annotated locations for XP_006531788.1

    UniProtKB/TrEMBL
    F6RWR5
    Conserved Domains (2) summary
    cl00388
    Location:1 → 59
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:67 → 186
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_011248620.3 → XP_011246922.1  glutathione S-transferase P-like isoform X2

    See identical proteins and their annotated locations for XP_011246922.1

    UniProtKB/TrEMBL
    F6RWR5
    Conserved Domains (2) summary
    cd03076
    Location:3 → 94
    GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:102 → 221
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  3. XM_030250874.1 → XP_030106734.1  glutathione S-transferase P-like isoform X3

    UniProtKB/TrEMBL
    F6RWR5
    Conserved Domains (2) summary
    cl00388
    Location:1 → 59
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:67 → 186
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein Strain
Heading Accession and Version

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