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Taf6l TATA-box binding protein associated factor 6 like [ Mus musculus (house mouse) ]

Gene ID: 225895, updated on 2-Nov-2024

Summary

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Official Symbol
Taf6lprovided by MGI
Official Full Name
TATA-box binding protein associated factor 6 likeprovided by MGI
Primary source
MGI:MGI:2444957
See related
Ensembl:ENSMUSG00000003680 AllianceGenome:MGI:2444957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Paf65a; 2810417N14Rik; C530024J06Rik
Summary
Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in tail. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 17.2), ovary adult (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Taf6l in Genome Data Viewer
Location:
19 A; 19 5.56 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8751718..8763781, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8774354..8786417, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45493 Neighboring gene nuclear RNA export factor 1 Neighboring gene transmembrane protein 223 Neighboring gene transmembrane protein 179B Neighboring gene interferon induced transmembrane protein 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2519 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide G Neighboring gene STARR-positive B cell enhancer ABC_E173 Neighboring gene zinc finger and BTB domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs. Chen J, et al. Endocrinology, 2009 Oct. PMID 19574399
  2. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Seruggia D, et al. Mol Cell, 2019 Jun 20. PMID 31005419, Free PMC Article
  3. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Floyd JA, et al. Nat Genet, 2003 Nov. PMID 14517553, Free PMC Article
  4. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. Schiltz RL, et al. J Biol Chem, 1999 Jan 15. PMID 9880483
  5. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network.
    Title: TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.
  2. Gonadotropin-releasing hormone-mediated phosphorylation of ERalpha in LbetaT2 pituitary cells results in its rapid association with p300-CBP-associated factor and the transcriptional activation of fosB.
    Title: Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC41377

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of somatic stem cell population maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Names
PAF65-alpha
PCAF-associated factor 65-alpha
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177798.1 → NP_001171269.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC025794, AK077149, BC028647
    Consensus CDS
    CCDS57134.1
    UniProtKB/TrEMBL
    A0A087WQC4, H3BJR2
    Related
    ENSMUSP00000135090.2, ENSMUST00000176496.8
    Conserved Domains (2) summary
    cd08050
    Location:20 → 304
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl21461
    Location:298 → 356
    Globin_like; Globin-like proteins

  2. NM_146092.2 → NP_666204.2  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AC025794, BC028647, BY295292
    Consensus CDS
    CCDS29546.2
    UniProtKB/TrEMBL
    H3BK01, K3W4L1
    Related
    ENSMUSP00000135193.2, ENSMUST00000176610.9
    Conserved Domains (2) summary
    cd08050
    Location:20 → 329
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl21461
    Location:323 → 381
    Globin_like; Globin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8751718..8763781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2K4.1 GenPept UniProtKB/Swiss-Prot:Q8R2K4

Gene LinkOut

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