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Tkfc triokinase, FMN cyclase [ Mus musculus (house mouse) ]

Gene ID: 225913, updated on 2-Nov-2024

Summary

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Official Symbol
Tkfcprovided by MGI
Official Full Name
triokinase, FMN cyclaseprovided by MGI
Primary source
MGI:MGI:2385084
See related
Ensembl:ENSMUSG00000034371 AllianceGenome:MGI:2385084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dak
Summary
Enables triokinase activity. Involved in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate. Predicted to be active in cytosol. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 116.1), kidney adult (RPKM 103.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Tkfc in Genome Data Viewer
Location:
19 A; 19 6.6 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10565153..10583257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10592197..10605482, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3 Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains Neighboring gene STARR-seq mESC enhancer starr_45554 Neighboring gene pepsinogen 5, group I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities. Hagopian K, et al. Biosci Rep, 2008 Apr. PMID 18429748, Free PMC Article
  2. The TKFC Ala185Thr variant, reported as 'null' for fructose metabolism, is fully active as triokinase. Ribeiro JM, et al. FEBS Lett, 2022 Jun. PMID 35114011
  3. Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance. Liu L, et al. Cell Metab, 2020 Oct 6. PMID 32818435
  4. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Massillon D, et al. Biochem J, 1994 Apr 1. PMID 8166629, Free PMC Article
  5. HNF4α is required for Tkfc promoter activation by ChREBP. Tsukamoto R, et al. Biosci Biotechnol Biochem, 2024 Jul 22. PMID 38782732

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HNF4alpha is required for Tkfc promoter activation by ChREBP.
    Title: HNF4α is required for Tkfc promoter activation by ChREBP.
  2. The TKFC Ala185Thr variant, reported as 'null' for fructose metabolism, is fully active as triokinase.
    Title: The TKFC Ala185Thr variant, reported as 'null' for fructose metabolism, is fully active as triokinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC28742

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD-AMP lyase (cyclizing) activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD-AMP lyase (cyclizing) activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerone kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerone kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables triokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triokinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IC
Inferred by Curator
more info
 PubMed 
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process through fructose-1-phosphate IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MDA-5 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
triokinase/FMN cyclase
Names
bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
dihydroxyacetone kinase 2 homolog
NP_001404794.1
NP_001404795.1
NP_001404796.1
NP_001404798.1
NP_001404799.1
NP_001404800.1
NP_663471.1
XP_006527004.1
XP_011245525.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417865.1 → NP_001404794.1  triokinase/FMN cyclase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/Swiss-Prot
    Q8VC30
    Related
    ENSMUSP00000157520.2, ENSMUST00000236607.2

  2. NM_001417866.1 → NP_001404795.1  triokinase/FMN cyclase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/Swiss-Prot
    Q8VC30

  3. NM_001417867.1 → NP_001404796.1  triokinase/FMN cyclase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/Swiss-Prot
    Q8VC30
    Related
    ENSMUSP00000158068.2, ENSMUST00000236950.2

  4. NM_001417869.1 → NP_001404798.1  triokinase/FMN cyclase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/TrEMBL
    Q3UTZ4
    Related
    ENSMUSP00000158115.2, ENSMUST00000237788.2

  5. NM_001417870.1 → NP_001404799.1  triokinase/FMN cyclase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/TrEMBL
    Q3UTZ4

  6. NM_001417871.1 → NP_001404800.1  triokinase/FMN cyclase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/TrEMBL
    Q3UTZ4

  7. NM_145496.2 → NP_663471.1  triokinase/FMN cyclase isoform 1

    See identical proteins and their annotated locations for NP_663471.1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    Consensus CDS
    CCDS37914.1
    UniProtKB/Swiss-Prot
    Q8VC30
    Related
    ENSMUSP00000044556.7, ENSMUST00000037678.7
    Conserved Domains (1) summary
    cl29418
    Location:4 → 570
    Dak2; DAK2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10565153..10583257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526941.5 → XP_006527004.1  triokinase/FMN cyclase isoform X1

    Conserved Domains (1) summary
    cl29418
    Location:56 → 622
    Dak2; DAK2 domain

  2. XM_011247223.3 → XP_011245525.1  triokinase/FMN cyclase isoform X3

    Conserved Domains (1) summary
    cl29418
    Location:2 → 565
    Dak2; DAK2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC30.1 GenPept UniProtKB/Swiss-Prot:Q8VC30

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