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Slc6a18 solute carrier family 6 (neurotransmitter transporter), member 18 [ Mus musculus (house mouse) ]

Gene ID: 22598, updated on 2-Nov-2024

Summary

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Official Symbol
Slc6a18provided by MGI
Official Full Name
solute carrier family 6 (neurotransmitter transporter), member 18provided by MGI
Primary source
MGI:MGI:1336892
See related
Ensembl:ENSMUSG00000021612 AllianceGenome:MGI:1336892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xt2; B0AT3; Xtrp2; D630001K16Rik
Summary
Enables neutral L-amino acid:sodium:chloride symporter activity. Involved in neutral amino acid transport and renal amino acid absorption. Acts upstream of or within amino acid transmembrane transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including metanephros. Orthologous to human SLC6A18 (solute carrier family 6 member 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward kidney adult (RPKM 132.5) See more
Orthologs
human all
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Genomic context

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See Slc6a18 in Genome Data Viewer
Location:
13 C1; 13 40.13 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73809869..73826142, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73661750..73678023, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CLPTM1-like Neighboring gene Tert 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_34994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:73778847-73779048 Neighboring gene telomerase reverse transcriptase Neighboring gene STARR-seq mESC enhancer starr_34995 Neighboring gene STARR-seq mESC enhancer starr_34996 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand Neighboring gene solute carrier family 12, member 7 Neighboring gene STARR-seq mESC enhancer starr_34997 Neighboring gene STARR-seq mESC enhancer starr_35002

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Quan H, et al. Mol Cell Biol, 2004 May. PMID 15121838, Free PMC Article
  2. Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria. Vanslambrouck JM, et al. Biochem J, 2010 May 27. PMID 20377526
  3. Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin. Fairweather SJ, et al. J Biol Chem, 2015 Oct 2. PMID 26240152, Free PMC Article
  4. Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus. Romeo E, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16174864
  5. Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. Singer D, et al. J Biol Chem, 2009 Jul 24. PMID 19478081, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin
    Title: Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
  2. In contrast to its association with ACE2 observed in Xenopus oocytes, experiments with ace2 and collectrin null mice demonstrate that in vivo it is Collectrin, a smaller homologue of ACE2, that is required for functional expression of XT2 in kidney.
    Title: Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.
  3. The XT2 orphan transporter is involved in glycine reabsorption, and the absence of this transporter is sufficient to cause hypertension.
    Title: Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neutral L-amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables neutral L-amino acid:sodium:chloride symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in renal amino acid absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sodium-dependent neutral amino acid transporter B(0)AT3
Names
X transporter protein 2
b(0)AT3
sodium and chloride dependent transporter Xtrp2
sodium- and chloride-dependent transporter XTRP2
solute carrier family 6 member 18
system B 0 neutral amino acid transporter AT3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040692.3 → NP_001035782.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform 1

    See identical proteins and their annotated locations for NP_001035782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC158359
    Consensus CDS
    CCDS36727.1
    UniProtKB/Swiss-Prot
    O88576, O88577, O88578, O88579, O88580, O88581, Q91XG6
    Related
    ENSMUSP00000152525.2, ENSMUST00000222029.2
    Conserved Domains (1) summary
    cd11517
    Location:16 → 591
    SLC6sbd_B0AT3; glycine transporter, B0AT3; solute-binding domain

  2. NM_001136087.2 → NP_001129559.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform 2

    See identical proteins and their annotated locations for NP_001129559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC158359, AK085473
    Consensus CDS
    CCDS49311.1
    UniProtKB/Swiss-Prot
    O88576
    Related
    ENSMUSP00000105302.3, ENSMUST00000109680.10
    Conserved Domains (1) summary
    cl00456
    Location:16 → 553
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001168643.1 → NP_001162114.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform 3

    See identical proteins and their annotated locations for NP_001162114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC158359, AK085258
    Consensus CDS
    CCDS88480.1
    UniProtKB/TrEMBL
    A0A217FL56
    Related
    ENSMUSP00000022105.9, ENSMUST00000022105.15
    Conserved Domains (1) summary
    cl00456
    Location:16 → 488
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_001168644.1 → NP_001162115.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform 4

    See identical proteins and their annotated locations for NP_001162115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC158359
    Consensus CDS
    CCDS49312.1
    UniProtKB/Swiss-Prot
    O88576
    Related
    ENSMUSP00000105301.3, ENSMUST00000109679.4
    Conserved Domains (1) summary
    cl00456
    Location:16 → 498
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. NM_001168645.1 → NP_001162116.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform 5

    See identical proteins and their annotated locations for NP_001162116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC158359
    Consensus CDS
    CCDS88479.1
    UniProtKB/Swiss-Prot
    O88576
    Related
    ENSMUSP00000152403.2, ENSMUST00000220650.2
    Conserved Domains (1) summary
    cl00456
    Location:16 → 460
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. NM_001168646.1 → NP_001162117.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform 6

    See identical proteins and their annotated locations for NP_001162117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 6), compared to isoform 1.
    Source sequence(s)
    AC158359
    Consensus CDS
    CCDS88481.1
    UniProtKB/Swiss-Prot
    O88576
    Related
    ENSMUSP00000152146.2, ENSMUST00000223074.2
    Conserved Domains (1) summary
    cd11517
    Location:16 → 581
    SLC6sbd_B0AT3; glycine transporter, B0AT3; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    73809869..73826142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011730.1: Suppressed sequence

    Description
    NM_011730.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88576.1 GenPept UniProtKB/Swiss-Prot:O88576

Gene LinkOut

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