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Ric1 RAB6A GEF complex partner 1 [ Mus musculus (house mouse) ]

Gene ID: 226089, updated on 2-Nov-2024

Summary

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Official Symbol
Ric1provided by MGI
Official Full Name
RAB6A GEF complex partner 1provided by MGI
Primary source
MGI:MGI:1924893
See related
Ensembl:ENSMUSG00000038658 AllianceGenome:MGI:1924893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1432; C030046E11Rik; C130057E09Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Predicted to be located in membrane. Predicted to be part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Predicted to be active in Golgi membrane and cytosol. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 7.7), subcutaneous fat pad adult (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ric1 in Genome Data Viewer
Location:
19 C1; 19 24.07 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29499637..29583909)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29522216..29605921)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29493177-29493330 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29505524-29505825 Neighboring gene STARR-seq mESC enhancer starr_45885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29528717-29528916 Neighboring gene RIKEN cDNA A930007I19 gene Neighboring gene STARR-positive B cell enhancer ABC_E3251 Neighboring gene STARR-positive B cell enhancer ABC_E8745 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene STARR-seq mESC enhancer starr_45891 Neighboring gene predicted gene, 36126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159151

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cranial skeletal system development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
guanine nucleotide exchange factor subunit RIC1
Names
RAB6A-GEF complex partner protein 1
protein RIC1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081319.1 → NP_001074788.1  guanine nucleotide exchange factor subunit RIC1

    Status: PROVISIONAL

    Source sequence(s)
    AC093339, AC114578
    Consensus CDS
    CCDS37951.1
    UniProtKB/Swiss-Prot
    A4GZ02, Q3U0Q6, Q3UWK1, Q69ZJ7
    UniProtKB/TrEMBL
    E9QPA1
    Related
    ENSMUSP00000043437.7, ENSMUST00000043610.13
    Conserved Domains (2) summary
    pfam07064
    Location:732 → 989
    RIC1; RIC1
    sd00039
    Location:254 → 304
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    29499637..29583909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250892.2 → XP_030106752.1  guanine nucleotide exchange factor subunit RIC1 isoform X2

    UniProtKB/TrEMBL
    F6S7U1
    Conserved Domains (2) summary
    sd00039
    Location:167 → 217
    7WD40; WD40 repeat [structural motif]
    pfam07064
    Location:645 → 902
    RIC1

  2. XM_036161563.1 → XP_036017456.1  guanine nucleotide exchange factor subunit RIC1 isoform X1

    UniProtKB/Swiss-Prot
    A4GZ02, Q3U0Q6, Q3UWK1, Q69ZJ7
    Conserved Domains (2) summary
    sd00039
    Location:254 → 304
    7WD40; WD40 repeat [structural motif]
    pfam07064
    Location:719 → 976
    RIC1

RNA

  1. XR_386464.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177641.2: Suppressed sequence

    Description
    NM_177641.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZJ7.2 GenPept UniProtKB/Swiss-Prot:Q69ZJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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