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Yes1 YES proto-oncogene 1, Src family tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 22612, updated on 2-Nov-2024

Summary

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Official Symbol
Yes1provided by MGI
Official Full Name
YES proto-oncogene 1, Src family tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:99147
See related
Ensembl:ENSMUSG00000014932 AllianceGenome:MGI:99147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Yes; p61-Yes
Summary
Enables protein tyrosine kinase activity. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; and positive regulation of macromolecule metabolic process. Located in actin filament and plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; gut; placenta; and vagal nerve trunk. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 4.0), CNS E11.5 (RPKM 3.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Yes1 in Genome Data Viewer
Location:
5 B1; 5 17.33 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32768502..32844410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32611171..32687066)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12795 Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene predicted gene 15614 Neighboring gene methyltransferase-like protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12798 Neighboring gene STARR-seq mESC enhancer starr_12799 Neighboring gene STARR-positive B cell enhancer ABC_E8048 Neighboring gene STARR-seq mESC enhancer starr_12801 Neighboring gene predicted gene 10461 Neighboring gene STARR-seq mESC enhancer starr_12803 Neighboring gene predicted gene 2420 Neighboring gene predicted gene, 52771 Neighboring gene STARR-seq mESC enhancer starr_12804 Neighboring gene phosphatidylserine decarboxylase Neighboring gene STARR-positive B cell enhancer ABC_E4751

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Translational upregulation of yes accompanies eIF4E-mediated oncogenic transformation. Defatta RJ, et al. Int J Oncol, 2003 Dec. PMID 14612945
  2. AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis. Francisco J, et al. Sci Rep, 2021 May 18. PMID 34006931, Free PMC Article
  3. Cellular functions regulated by Src family kinases. Thomas SM, et al. Annu Rev Cell Dev Biol, 1997. PMID 9442882
  4. YES1 activation elicited by heat stress is anti-apoptotic in mouse pachytene spermatocytes. Liang Y, et al. Biol Reprod, 2013 Dec. PMID 24132961
  5. Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase. Klages S, et al. Oncogene, 1993 Mar. PMID 8437854

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue.
    Title: Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue.
  2. AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
    Title: AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis.
  3. Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in ice.
    Title: Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in mice.
  4. Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.
    Title: Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.
  5. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1.
    Title: MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1.
  6. a novel insight into the molecular mechanisms underlying lung development and contribute to a better understanding of the characteristics of TAZ-transcriptional coactivator with PDZ-binding motif and YAP
    Title: Epithelial Expression of YAP and TAZ Is Sequentially Required in Lung Development.
  7. results suggest that Yes-associated protein fine-tunes the expression of genes associated with spermatogonial fate commitment, but that its loss is not sufficient to alter spermatogenesis in vivo
    Title: Yes-associated protein expression in germ cells is dispensable for spermatogenesis in mice.
  8. Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase.
    Title: Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.
  9. serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP/TEAD pathway
    Title: Serum Inter-α-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells.
  10. Differentiation of embryonic stem cells is driven by c-Src is antagonized by c-Yes.
    Title: c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization, intracellular component ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Yes
Names
Yamaguchi sarcoma viral (v-yes) oncogene homolog 1
proto-oncogene c-Yes
proto-oncogene tyrosine-protein kinase Yes
viral oncogene yes homolog
NP_001192061.1
NP_001192062.1
NP_033561.1
XP_036020892.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205132.1 → NP_001192061.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_001192061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC091274, AC166934
    Consensus CDS
    CCDS39061.1
    UniProtKB/Swiss-Prot
    Q04736
    UniProtKB/TrEMBL
    Q3TJI7, Q8C762, Q8CBP1
    Related
    ENSMUSP00000144001.2, ENSMUST00000202543.4
    Conserved Domains (4) summary
    cd09933
    Location:152 → 251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92 → 149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262 → 540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    pfam07714
    Location:275 → 524
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_001205133.1 → NP_001192062.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_001192062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in both the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC091274, AC166934
    Consensus CDS
    CCDS39061.1
    UniProtKB/Swiss-Prot
    Q04736
    UniProtKB/TrEMBL
    Q3TJI7, Q8C762, Q8CBP1
    Related
    ENSMUSP00000132161.3, ENSMUST00000168707.6
    Conserved Domains (4) summary
    cd09933
    Location:152 → 251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92 → 149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262 → 540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    pfam07714
    Location:275 → 524
    Pkinase_Tyr; Protein tyrosine kinase

  3. NM_009535.3 → NP_033561.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_033561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC091274, AC166934, AK167420
    Consensus CDS
    CCDS39061.1
    UniProtKB/Swiss-Prot
    Q04736
    UniProtKB/TrEMBL
    Q3TJI7, Q8C762, Q8CBP1
    Related
    ENSMUSP00000072154.7, ENSMUST00000072311.13
    Conserved Domains (4) summary
    cd09933
    Location:152 → 251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92 → 149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262 → 540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    pfam07714
    Location:275 → 524
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    32768502..32844410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164999.1 → XP_036020892.1  tyrosine-protein kinase Yes isoform X1

    Conserved Domains (3) summary
    cd09933
    Location:152 → 251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92 → 149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cl21453
    Location:262 → 351
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04736.3 GenPept UniProtKB/Swiss-Prot:Q04736

Gene LinkOut

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