Cox15 cytochrome c oxidase assembly protein 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cox15provided by MGI
Official Full Name: cytochrome c oxidase assembly protein 15provided by MGI
Primary source: MGI:MGI:1920112
See related: Ensembl:ENSMUSG00000040018 AllianceGenome:MGI:1920112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HAS; 2900026G05Rik
Summary: Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor and oxidoreductase activity, acting on the CH-CH group of donors. Predicted to be involved in cytochrome complex assembly and heme A biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 15.9), large intestine adult (RPKM 13.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.67 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (43721693..43741439, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (43733254..43753000, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237946

NoName (e-PCR)
- UniSTS:237949

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cytochrome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in cytochrome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in heme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme A biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heme A biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
part_of cytochrome complex	IEA Inferred from Electronic Annotation more info
part_of cytochrome complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heme A synthase COX15

Names: COX15 homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX15 homolog

NP_659123.2

EC 1.17.99.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.