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Atrnl1 attractin like 1 [ Mus musculus (house mouse) ]

Gene ID: 226255, updated on 2-Nov-2024

Summary

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Official Symbol
Atrnl1provided by MGI
Official Full Name
attractin like 1provided by MGI
Primary source
MGI:MGI:2147749
See related
Ensembl:ENSMUSG00000054843 AllianceGenome:MGI:2147749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alp; Atrnl; Atrnlp
Summary
Predicted to enable Notch binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human ATRNL1 (attractin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 10.7), frontal lobe adult (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atrnl1 in Genome Data Viewer
Location:
19 D2; 19 53.31 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (57599248..58121775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (57610960..58133343)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6720468P15 gene Neighboring gene STARR-seq mESC enhancer starr_46555 Neighboring gene STARR-seq mESC enhancer starr_46556 Neighboring gene predicted gene, 32932 Neighboring gene STARR-positive B cell enhancer mm9_chr19:57717570-57717871 Neighboring gene STARR-positive B cell enhancer mm9_chr19:57729589-57729890 Neighboring gene STARR-seq mESC enhancer starr_46558 Neighboring gene STARR-seq mESC enhancer starr_46561 Neighboring gene STARR-seq mESC enhancer starr_46562 Neighboring gene STARR-seq mESC enhancer starr_46563 Neighboring gene STARR-seq mESC enhancer starr_46566 Neighboring gene STARR-seq mESC enhancer starr_46567 Neighboring gene predicted gene, 52385 Neighboring gene STARR-seq mESC enhancer starr_46569 Neighboring gene STARR-seq mESC enhancer starr_46571 Neighboring gene predicted gene, 32980 Neighboring gene microRNA 5623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:58218359-58218542 Neighboring gene predicted gene, 50287 Neighboring gene STARR-seq mESC enhancer starr_46573 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 1 Neighboring gene predicted gene, 46650 Neighboring gene predicted gene 10007

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic analysis of attractin homologs. Walker WP, et al. Genesis, 2007 Dec. PMID 18064672
  2. Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Haqq AM, et al. Biochem J, 2003 Dec 15. PMID 14531729, Free PMC Article
  3. Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification. Stylianou IM, et al. Genetics, 2008 Mar. PMID 18245842, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Over-expression of ATRNL1 compensates for loss of ATRN.
    Title: Genetic analysis of attractin homologs.
  2. Identification of attractin-like protein as a binding partner of melanocortin-4 receptor (attractin-like protein).
    Title: Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
attractin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181415.4 → NP_852080.3  attractin-like protein 1 precursor

    See identical proteins and their annotated locations for NP_852080.3

    Status: VALIDATED

    Source sequence(s)
    AK147492, AY688677
    Consensus CDS
    CCDS29928.1
    UniProtKB/Swiss-Prot
    Q3UHB0, Q68HV2, Q6A051, Q80VI3, Q8BKS4, Q8K0P5
    Related
    ENSMUSP00000076514.6, ENSMUST00000077282.7
    Conserved Domains (8) summary
    cd03597
    Location:747 → 873
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00041
    Location:92 → 207
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:1012 → 1057
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:520 → 573
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:888 → 937
    PSI; Plexin repeat
    pfam13418
    Location:467 → 513
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:351 → 391
    Kelch_5; Kelch motif
    cl19567
    Location:234 → 279
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    57599248..58121775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250921.2 → XP_030106781.1  attractin-like protein 1 isoform X7

    Conserved Domains (4) summary
    cd03597
    Location:215 → 341
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00055
    Location:480 → 525
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam01437
    Location:356 → 404
    PSI; Plexin repeat
    pfam13854
    Location:48 → 81
    Kelch_5; Kelch motif

  2. XM_011247244.2 → XP_011245546.1  attractin-like protein 1 isoform X3

    Conserved Domains (9) summary
    cd03597
    Location:704 → 830
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    PLN02153
    Location:410 → 556
    PLN02153; epithiospecifier protein
    PHA03098
    Location:272 → 410
    PHA03098; kelch-like protein; Provisional
    cd00041
    Location:92 → 162
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:969 → 1014
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:477 → 530
    Kelch; KELCH repeat [structural motif]
    pfam01414
    Location:178 → 236
    DSL; Delta serrate ligand
    pfam01437
    Location:845 → 893
    PSI; Plexin repeat
    pfam13854
    Location:308 → 348
    Kelch_5; Kelch motif

  3. XM_006527049.4 → XP_006527112.1  attractin-like protein 1 isoform X1

    Conserved Domains (9) summary
    cd03597
    Location:747 → 873
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    PLN02153
    Location:453 → 599
    PLN02153; epithiospecifier protein
    PHA03098
    Location:315 → 453
    PHA03098; kelch-like protein; Provisional
    cd00041
    Location:92 → 207
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:1012 → 1057
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:520 → 573
    Kelch; KELCH repeat [structural motif]
    pfam01414
    Location:221 → 279
    DSL; Delta serrate ligand
    pfam01437
    Location:888 → 936
    PSI; Plexin repeat
    pfam13854
    Location:351 → 391
    Kelch_5; Kelch motif

  4. XM_036161583.1 → XP_036017476.1  attractin-like protein 1 isoform X2

    Conserved Domains (9) summary
    cd03597
    Location:747 → 873
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    PLN02153
    Location:453 → 599
    PLN02153; epithiospecifier protein
    PHA03098
    Location:315 → 453
    PHA03098; kelch-like protein; Provisional
    cd00041
    Location:92 → 207
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:1012 → 1057
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:520 → 573
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:888 → 937
    PSI; Plexin repeat
    pfam13854
    Location:351 → 391
    Kelch_5; Kelch motif
    cl19567
    Location:234 → 279
    DSL; Delta serrate ligand

  5. XM_036161584.1 → XP_036017477.1  attractin-like protein 1 isoform X4

    Conserved Domains (9) summary
    cd03597
    Location:747 → 873
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    PLN02153
    Location:453 → 599
    PLN02153; epithiospecifier protein
    PHA03098
    Location:315 → 453
    PHA03098; kelch-like protein; Provisional
    cd00041
    Location:92 → 207
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:1012 → 1057
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:520 → 573
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:888 → 937
    PSI; Plexin repeat
    pfam13854
    Location:351 → 391
    Kelch_5; Kelch motif
    cl19567
    Location:234 → 279
    DSL; Delta serrate ligand

  6. XM_006527051.4 → XP_006527114.1  attractin-like protein 1 isoform X5

    Conserved Domains (9) summary
    cd03597
    Location:747 → 873
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    PLN02153
    Location:453 → 599
    PLN02153; epithiospecifier protein
    PLN02193
    Location:299 → 386
    PLN02193; nitrile-specifier protein
    cd00041
    Location:92 → 207
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:1012 → 1057
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:520 → 573
    Kelch; KELCH repeat [structural motif]
    pfam01414
    Location:221 → 279
    DSL; Delta serrate ligand
    pfam01437
    Location:888 → 936
    PSI; Plexin repeat
    pfam13854
    Location:351 → 391
    Kelch_5; Kelch motif

  7. XM_006527052.4 → XP_006527115.1  attractin-like protein 1 isoform X6

    Conserved Domains (9) summary
    cd03597
    Location:747 → 873
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    PLN02153
    Location:453 → 599
    PLN02153; epithiospecifier protein
    PHA03098
    Location:315 → 453
    PHA03098; kelch-like protein; Provisional
    cd00041
    Location:92 → 207
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:1012 → 1057
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:520 → 573
    Kelch; KELCH repeat [structural motif]
    pfam01414
    Location:221 → 279
    DSL; Delta serrate ligand
    pfam01437
    Location:888 → 936
    PSI; Plexin repeat
    pfam13854
    Location:351 → 391
    Kelch_5; Kelch motif

RNA

  1. XR_001782587.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A051.2 GenPept UniProtKB/Swiss-Prot:Q6A051

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