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Slc23a3 solute carrier family 23 (nucleobase transporters), member 3 [ Mus musculus (house mouse) ]

Gene ID: 22626, updated on 2-Nov-2024

Summary

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Official Symbol
Slc23a3provided by MGI
Official Full Name
solute carrier family 23 (nucleobase transporters), member 3provided by MGI
Primary source
MGI:MGI:104516
See related
Ensembl:ENSMUSG00000026205 AllianceGenome:MGI:104516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SVCT3; Yspl1
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in hypoxanthine transport. Predicted to be located in cytoplasm and membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human SLC23A3 (solute carrier family 23 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 6.4), kidney adult (RPKM 4.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Slc23a3 in Genome Data Viewer
Location:
1 C4; 1 38.6 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75102185..75112113, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75125541..75135223, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Indian hedgehog Neighboring gene non-homologous end joining factor 1 Neighboring gene STARR-seq mESC enhancer starr_01350 Neighboring gene STARR-seq mESC enhancer starr_01351 Neighboring gene STARR-seq mESC enhancer starr_01352 Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene reticulophagy regulator family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies. Guimarães MJ, et al. Development, 1995 Oct. PMID 7588067
  2. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC143681, MGC143682

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in hypoxanthine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in hypoxanthine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 23 member 3
Names
Na(+)/L-ascorbic acid transporter 3
YSPL-1
sodium-dependent vitamin C transporter 3
yolk sac permease-like molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194333.3 → NP_919314.2  solute carrier family 23 member 3

    See identical proteins and their annotated locations for NP_919314.2

    Status: VALIDATED

    Source sequence(s)
    BC094893, BC117790, CJ065822
    Consensus CDS
    CCDS15062.1
    UniProtKB/Swiss-Prot
    Q149H3, Q4VBX5, Q60850, Q60851, Q60852, Q60853, Q78E82, Q78E83, Q78E84
    UniProtKB/TrEMBL
    A0A0R4J067
    Related
    ENSMUSP00000027405.5, ENSMUST00000027405.6
    Conserved Domains (2) summary
    pfam00860
    Location:83 → 476
    Xan_ur_permease; Permease family
    cl23746
    Location:87 → 482
    HCO3_cotransp; HCO3- transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75102185..75112113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163732.1 → XP_036019625.1  solute carrier family 23 member 3 isoform X2

    UniProtKB/Swiss-Prot
    Q149H3, Q4VBX5, Q60850, Q60851, Q60852, Q60853, Q78E82, Q78E83, Q78E84
    Conserved Domains (1) summary
    pfam00860
    Location:6 → 370
    Xan_ur_permease; Permease family

  2. XM_006496481.2 → XP_006496544.1  solute carrier family 23 member 3 isoform X4

    Conserved Domains (1) summary
    cl23746
    Location:16 → 259
    Xan_ur_permease; Permease family

  3. XM_006496480.2 → XP_006496543.1  solute carrier family 23 member 3 isoform X3

    Conserved Domains (1) summary
    cl23746
    Location:83 → 332
    Xan_ur_permease; Permease family

  4. XM_030253070.1 → XP_030108930.1  solute carrier family 23 member 3 isoform X5

    UniProtKB/Swiss-Prot
    Q149H3, Q4VBX5, Q60850, Q60851, Q60852, Q60853, Q78E82, Q78E83, Q78E84
    Conserved Domains (1) summary
    cl23746
    Location:83 → 359
    Xan_ur_permease; Permease family

  5. XM_006496479.2 → XP_006496542.1  solute carrier family 23 member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q149H3, Q4VBX5, Q60850, Q60851, Q60852, Q60853, Q78E82, Q78E83, Q78E84
    Conserved Domains (1) summary
    pfam00860
    Location:83 → 476
    Xan_ur_permease; Permease family

RNA

  1. XR_373540.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60850.1 GenPept UniProtKB/Swiss-Prot:Q60850

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