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Plagl1 pleiomorphic adenoma gene-like 1 [ Mus musculus (house mouse) ]

Gene ID: 22634, updated on 2-Nov-2024

Summary

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Official Symbol
Plagl1provided by MGI
Official Full Name
pleiomorphic adenoma gene-like 1provided by MGI
Primary source
MGI:MGI:1100874
See related
Ensembl:ENSMUSG00000019817 AllianceGenome:MGI:1100874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lot1; Zac1; 2610311E24Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of gene expression and skeletal muscle cell differentiation. Predicted to be located in Golgi apparatus and nuclear body. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and sensory organ. Orthologous to human PLAGL1 (PLAG1 like zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 270.7), CNS E11.5 (RPKM 64.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Plagl1 in Genome Data Viewer
Location:
10 A2; 10 4.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (12966576..13007438)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13090832..13131694)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5119 Neighboring gene STARR-seq mESC enhancer starr_25807 Neighboring gene splicing factor 3b, subunit 5 Neighboring gene predicted gene, 40602 Neighboring gene STARR-seq mESC enhancer starr_25810 Neighboring gene hydatidiform mole associated and imprinted transcript Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation. Li C, et al. J Cell Mol Med, 2024 Oct. PMID 39365284, Free PMC Article
  2. Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells. Du X, et al. Diabetes Metab Res Rev, 2012 Nov. PMID 22865650, Free PMC Article
  3. Zac1 promotes a Müller glial cell fate and interferes with retinal ganglion cell differentiation in Xenopus retina. Ma L, et al. Dev Dyn, 2007 Jan. PMID 17072860
  4. Down-regulation of the transcription factor ZAC1 upon pre- and postconditioning protects against I/R injury in the mouse myocardium. Vincent A, et al. Cardiovasc Res, 2012 May 1. PMID 22106414
  5. Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: differential phenotype of the Zac1-expressing cells during development. Valente T, et al. Dev Dyn, 2005 Jun. PMID 15844099

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation.
    Title: PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation.
  2. Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
    Title: Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
  3. The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
    Title: The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
  4. Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
    Title: Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
  5. Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.
    Title: Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.
  6. PLAGL1 may regulate hypothalamic hypocretin transcription.
    Title: Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription.
  7. Zac1/GPR39 system promotes the formation of type II muscle fibers by phosphorylation of CaMK-II. Cells lacking Zac1/GPR39 system tend to remain stemness and form type I muscle fibers after induced differentiation.
    Title: Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
  8. Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition.
    Title: Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network.
  9. expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors.
    Title: Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming.
  10. Transcription factor MEF2 and Zac1 mediate MIF-induced GLUT4 expression through CD74-dependent AMPK activation in cardiomyocytes
    Title: Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein PLAGL1
Names
zinc finger protein regulator of apoptosis and cell cycle arrest

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364643.1 → NP_001351572.1  zinc finger protein PLAGL1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AK142052, AK142210, BC065150
    Consensus CDS
    CCDS87960.1
    UniProtKB/TrEMBL
    Q3UQW2
    Related
    ENSMUSP00000112889.2, ENSMUST00000121325.8
    Conserved Domains (3) summary
    COG5189
    Location:29 → 109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:6 → 26
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:49 → 73
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001364644.1 → NP_001351573.1  zinc finger protein PLAGL1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AK142052, AK142210, BC065150
    Consensus CDS
    CCDS87960.1
    UniProtKB/TrEMBL
    Q3UQW2
    Related
    ENSMUSP00000113710.2, ENSMUST00000121766.8
    Conserved Domains (3) summary
    COG5189
    Location:29 → 109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:6 → 26
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:49 → 73
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001364645.1 → NP_001351574.1  zinc finger protein PLAGL1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691505, AL713985
    Consensus CDS
    CCDS87960.1
    UniProtKB/TrEMBL
    Q3UQW2
    Conserved Domains (3) summary
    COG5189
    Location:29 → 109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:6 → 26
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:49 → 73
    zf-H2C2_2; Zinc-finger double domain

  4. NM_009538.3 → NP_033564.2  zinc finger protein PLAGL1 isoform a

    See identical proteins and their annotated locations for NP_033564.2

    Status: VALIDATED

    Source sequence(s)
    BC065150
    Consensus CDS
    CCDS48501.1
    UniProtKB/TrEMBL
    Q9JLQ4
    Related
    ENSMUSP00000112847.2, ENSMUST00000121646.8
    Conserved Domains (2) summary
    sd00017
    Location:6 → 26
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:49 → 73
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    12966576..13007438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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