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R3hdm1 R3H domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 226412, updated on 2-Nov-2024

Summary

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Official Symbol
R3hdm1provided by MGI
Official Full Name
R3H domain containing 1provided by MGI
Primary source
MGI:MGI:2448514
See related
Ensembl:ENSMUSG00000056211 AllianceGenome:MGI:2448514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R3hdm
Summary
Is expressed in several structures, including adipose tissue; alimentary system; brain; eye; and genitourinary system. Orthologous to human R3HDM1 (R3H domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 66.1), frontal lobe adult (RPKM 51.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See R3hdm1 in Genome Data Viewer
Location:
1 E3; 1 55.8 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128031016..128165475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128103282..128237738)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene zinc finger, RAN-binding domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129912788-129913088 Neighboring gene My020 protein Neighboring gene STARR-seq mESC enhancer starr_02156 Neighboring gene ribosomal protein L28, pseudogene 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129973654-129973955 Neighboring gene STARR-positive B cell enhancer ABC_E991 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129999606-129999907 Neighboring gene male-enhanced antigen 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02158 Neighboring gene STARR-seq mESC enhancer starr_02159 Neighboring gene microRNA 128-1 Neighboring gene STARR-positive B cell enhancer ABC_E9060 Neighboring gene predicted gene, 41949 Neighboring gene UBX domain protein 4 Neighboring gene lactase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts. Rehfeld F, et al. Nat Commun, 2018 Mar 26. PMID 29581509, Free PMC Article
  2. MicroRNA profile of the developing mouse retina. Hackler L Jr, et al. Invest Ophthalmol Vis Sci, 2010 Apr. PMID 19933188, Free PMC Article
  3. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article
  4. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
R3H domain-containing protein 1
Names
R3H domain (binds single-stranded nucleic acids)
R3H domain 1 (binds single-stranded nucleic acids)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357482.1 → NP_001344411.1  R3H domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC161809
    Consensus CDS
    CCDS15250.1
    UniProtKB/TrEMBL
    E9Q9Q2
    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain
    cl25764
    Location:682 → 917
    PAT1; Topoisomerase II-associated protein PAT1

  2. NM_181750.2 → NP_861415.2  R3H domain-containing protein 1

    See identical proteins and their annotated locations for NP_861415.2

    Status: VALIDATED

    Source sequence(s)
    BC032160, BC049181, BY017957
    Consensus CDS
    CCDS15250.1
    UniProtKB/TrEMBL
    E9Q9Q2
    Related
    ENSMUSP00000043103.5, ENSMUST00000036288.11
    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain
    cl25764
    Location:682 → 917
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    128031016..128165475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253185.2 → XP_030109045.1  R3H domain-containing protein 1 isoform X17

    Conserved Domains (1) summary
    pfam12752
    Location:38 → 89
    SUZ; SUZ domain

  2. XM_036163899.1 → XP_036019792.1  R3H domain-containing protein 1 isoform X17

    Conserved Domains (1) summary
    pfam12752
    Location:38 → 89
    SUZ; SUZ domain

  3. XM_006529417.4 → XP_006529480.1  R3H domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    cd02642
    Location:153 → 214
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam03157
    Location:475 → 885
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:237 → 288
    SUZ; SUZ domain

  4. XM_030253186.2 → XP_030109046.1  R3H domain-containing protein 1 isoform X17

    Conserved Domains (1) summary
    pfam12752
    Location:38 → 89
    SUZ; SUZ domain

  5. XM_006529420.4 → XP_006529483.1  R3H domain-containing protein 1 isoform X4

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 355
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam03157
    Location:445 → 855
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  6. XM_030253188.2 → XP_030109048.1  R3H domain-containing protein 1 isoform X18

    Conserved Domains (2) summary
    pfam09770
    Location:253 → 524
    PAT1; Topoisomerase II-associated protein PAT1
    pfam12752
    Location:38 → 89
    SUZ; SUZ domain

  7. XM_017319914.3 → XP_017175403.1  R3H domain-containing protein 1 isoform X19

    Conserved Domains (2) summary
    pfam09770
    Location:400 → 654
    PAT1; Topoisomerase II-associated protein PAT1
    pfam12752
    Location:38 → 89
    SUZ; SUZ domain

  8. XM_006529419.4 → XP_006529482.1  R3H domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006529482.1

    UniProtKB/TrEMBL
    B9EHE8
    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:673 → 959
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  9. XM_006529421.4 → XP_006529484.1  R3H domain-containing protein 1 isoform X8

    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam03157
    Location:401 → 814
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  10. XM_006529423.5 → XP_006529486.1  R3H domain-containing protein 1 isoform X11

    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:588 → 874
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  11. XM_006529418.4 → XP_006529481.1  R3H domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  12. XM_030253147.2 → XP_030109007.1  R3H domain-containing protein 1 isoform X5

    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:657 → 943
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  13. XM_006529422.4 → XP_006529485.1  R3H domain-containing protein 1 isoform X10

    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam03157
    Location:388 → 798
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  14. XM_036163855.1 → XP_036019748.1  R3H domain-containing protein 1 isoform X13

    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:512 → 858
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  15. XM_030253152.2 → XP_030109012.1  R3H domain-containing protein 1 isoform X7

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 355
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam09606
    Location:629 → 915
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  16. XM_006529424.5 → XP_006529487.1  R3H domain-containing protein 1 isoform X12

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 355
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam03157
    Location:357 → 770
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  17. XM_036163872.1 → XP_036019765.1  R3H domain-containing protein 1 isoform X15

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 355
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam09606
    Location:484 → 830
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  18. XM_030253150.2 → XP_030109010.1  R3H domain-containing protein 1 isoform X6

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 345
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam03157
    Location:429 → 839
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  19. XM_030253156.2 → XP_030109016.1  R3H domain-containing protein 1 isoform X9

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 345
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam09606
    Location:613 → 899
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  20. XM_030253164.2 → XP_030109024.1  R3H domain-containing protein 1 isoform X14

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 345
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam03157
    Location:344 → 754
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  21. XM_030253181.2 → XP_030109041.1  R3H domain-containing protein 1 isoform X16

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 345
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam09606
    Location:528 → 814
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  22. XM_036163897.1 → XP_036019790.1  R3H domain-containing protein 1 isoform X17

    Conserved Domains (1) summary
    pfam12752
    Location:38 → 89
    SUZ; SUZ domain

  23. XM_030253144.2 → XP_030109004.1  R3H domain-containing protein 1 isoform X4

    Conserved Domains (4) summary
    cd02642
    Location:123 → 184
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    PTZ00440
    Location:8 → 355
    PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    pfam03157
    Location:445 → 855
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam12752
    Location:207 → 258
    SUZ; SUZ domain

  24. XM_017319906.3 → XP_017175395.1  R3H domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    B9EHE8
    Conserved Domains (3) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam09606
    Location:673 → 959
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

  25. XM_036163828.1 → XP_036019721.1  R3H domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd02642
    Location:167 → 228
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
    pfam12752
    Location:251 → 302
    SUZ; SUZ domain

RNA

  1. XR_001784078.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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