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Dyrk3 dual-specificity tyrosine phosphorylation regulated kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 226419, updated on 14-Nov-2024

Summary

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Official Symbol
Dyrk3provided by MGI
Official Full Name
dual-specificity tyrosine phosphorylation regulated kinase 3provided by MGI
Primary source
MGI:MGI:1330300
See related
Ensembl:ENSMUSG00000016526 AllianceGenome:MGI:1330300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including erythrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; and protein phosphorylation. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; musculature; and nasal cavity epithelium. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 67.2), liver E14.5 (RPKM 10.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Dyrk3 in Genome Data Viewer
Location:
1 E4; 1 56.9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131056178..131065991, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131128441..131138234, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene MAP kinase-activated protein kinase 2 Neighboring gene predicted gene, 25549 Neighboring gene STARR-positive B cell enhancer ABC_E5794 Neighboring gene predicted gene, 51643 Neighboring gene STARR-seq mESC enhancer starr_02208 Neighboring gene STARR-positive B cell enhancer ABC_E5795 Neighboring gene STARR-seq mESC enhancer starr_02210 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene Ras association (RalGDS/AF-6) domain family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E11692 Neighboring gene STARR-seq mESC enhancer starr_02214 Neighboring gene bystin-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DYRK3 contributes to differentiation and hypoxic control in neuroblastoma. Ivanova E, et al. Biochem Biophys Res Commun, 2021 Aug 27. PMID 34171798
  2. DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. Zhang D, et al. Genomics, 2005 Jan. PMID 15607427
  3. DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. Li K, et al. J Biol Chem, 2002 Dec 6. PMID 12356771
  4. DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. Bogacheva O, et al. J Biol Chem, 2008 Dec 26. PMID 18854306, Free PMC Article
  5. mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development. Geiger JN, et al. Blood, 2001 Feb 15. PMID 11159515

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DYRK3 contributes to differentiation and hypoxic control in neuroblastoma.
    Title: DYRK3 contributes to differentiation and hypoxic control in neuroblastoma.
  2. Study identified the dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) as a protein with the ability to condense P-granule-like speckles in the cytosol and to prevent stress granule dissolution via its N-terminal domain when it is in a kinase-inactive form.
    Title: Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
  3. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
    Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
  4. DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia
    Title: DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.
  5. DYRK3, expression is strong in erythroid cells and testis, but is also detected in adult kidney and liver
    Title: DYRK gene structure and erythroid-restricted features of DYRK3 gene expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear speck organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear speck organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in organelle disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in organelle disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of cell cycle G2/M phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle G2/M phase transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cellular response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular response to stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stress granule disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress granule disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 3
Names
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
NP_001404999.1
NP_001405000.1
NP_001405001.1
NP_001405002.1
NP_001405003.1
NP_001405004.1
NP_663483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418070.1 → NP_001404999.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL513351

  2. NM_001418071.1 → NP_001405000.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL513351

  3. NM_001418072.1 → NP_001405001.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL513351

  4. NM_001418073.1 → NP_001405002.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL513351

  5. NM_001418074.1 → NP_001405003.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL513351

  6. NM_001418075.1 → NP_001405004.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL513351

  7. NM_145508.3 → NP_663483.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a

    See identical proteins and their annotated locations for NP_663483.1

    Status: VALIDATED

    Source sequence(s)
    AL513351
    Consensus CDS
    CCDS15267.1
    UniProtKB/Swiss-Prot
    Q8BM34, Q922Y0
    Related
    ENSMUSP00000016670.8, ENSMUST00000016670.9
    Conserved Domains (2) summary
    smart00220
    Location:208 → 521
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:142 → 521
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131056178..131065991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922Y0.1 GenPept UniProtKB/Swiss-Prot:Q922Y0

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